Nampt Antibody, HRP conjugated

^{Rare Species}

說明書

中文名稱：

Nampt兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA015422LB01RA
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Rattus norvegicus (Rat) Nampt Polyclonal antibody
Uniprot No.：

Q80Z29
基因名：

Nampt
別名：

Nampt antibody; Pbef1 antibody; Nicotinamide phosphoribosyltransferase antibody; NAmPRTase antibody; Nampt antibody; EC 2.4.2.12 antibody; Pre-B-cell colony-enhancing factor 1 homolog antibody; PBEF antibody; Visfatin antibody
宿主：

Rabbit
反應(yīng)種屬：

Rat
免疫原：

Recombinant Rat Nampt protein (231-491AA)
免疫原種屬：

Rattus norvegicus (Rat)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Antigen Affinity purified & Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
基因功能參考文獻：
1. A Strong association was observed among fasting blood glucose, serum visfatin and trace elements levels of high fat diet and type 2 diabetes mellitus PMID: 29772226
2. Our findings suggest that NAMPT inhibition may be a novel therapeutic approach for I/R-induced lung injury. The protective effects involve the suppression of multiple signal pathways. PMID: 28438162
3. Thus, it can be suggested that visfatin may play an important role in testicular aging by regulating testicular steroidogenesis and spermatogenesis. PMID: 28163205
4. visfatin plays a dual role in the apoptosis in rat Mesenteric lymph nodes, which is mediated by both the mitochondrial apoptotic pathway and the death-receptor apoptotic pathway. PMID: 26857566
5. this study shows that serum visfatin levels, and white adipose tissue and hepatic visfatin mRNA levels of both male and female rats were increased by LPS injection PMID: 27083000
6. Visfatin was expressed in the rats' retinas, mainly in the retinal nerve fibre layer, inner plexiform layer and outer plexiform layer. As the development of diabetes mellitus course, its expression was gradually increased. PMID: 26694625
7. NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity PMID: 27035562
8. Report retinal toxicity of NAMPT inhibitors. PMID: 25505128
9. visfatin could participate in the inflammatory process in rat spleen by modulating the macrophages and inflammatory cytokines. PMID: 25358398
10. Visfatin induced the expression of alphaSMA in cultureactivated rat HSC, which was accompanied by a significant increase in collagen types I and III. PMID: 25351242
11. These data are the first to show that Nampt inhibits myometrial contractility and does so more potently than leptin. PMID: 25645057
12. Central visfatin improved glucose homeostasis by increasing insulin secretion and insulin sensitivity at euglycemia through the hypothalamus in diabetic rats. PMID: 24332931
13. role in myocardial inflammation during endotoxemia PMID: 23831038
14. Data indicate that nicotinamide phosphoribosyltransferase (NAMPT) mRNA and protein were increased in the kidneys with streptozotocin-induced diabetes. PMID: 24287278
15. CR-induced beneficial effects in oxidative stress, mitochondrial biogenesis, and metabolic adaptation require NAMPT. PMID: 23946338
16. visfatin plays a critical role in cardioprotection by suppressing myocardial apoptosis via AMPK activation PMID: 23065734
17. Nampt promotes neuronal survival through inducing autophagy. PMID: 22113203
18. Visfatin expression was increased mainly through the AT1-R-JAK/STAT pathway in the process of Ang II-induced cardiomyocyte hypertrophy. PMID: 21841463
19. The expression of visfatin is closely associated with the expression of proinflammatory cytokines in FFA-induced inflammation and is significantly decreased by NF-kappaB inhibition in HepG2 cells. PMID: 21664630
20. Our findings reveal that Nampt protects against ischemic stroke through rescuing neurons from death via the SIRT1-dependent AMPK pathway and indicate that Nampt is a new therapeutic target for stroke. PMID: 21246601
21. results of the present study demonstrate that serum visfatin levels in Lyon hypertensive rats are elevated and are associated with lipid metabolic abnormalities PMID: 20456420
22. No differences of serum visfatin levels were observed between spontaneously hypertensive rats and Wistar-Kyoto rats. Serum visfatin levels were significantly correlated to weights of skeletal muscle. PMID: 20658215
23. Visfatin exhibits important autocrine effects on sensitivity of liver cells to insulin action possibly through its effects on NAD biosynthesis. PMID: 19929131
24. Exercise training induced SIRT1 activity due to the positive effect of exercise on the activity of nicotinamide phosphoribosyltransferase (NAMPT) and thereby the production of sirtuin-fueling NAD(+). PMID: 19913571
25. PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle PMID: 12782293
26. relative visfatin gene expression is not associated with the metabolic syndrome in WOKW rats [Pbef, also called visfatin] PMID: 15922301
27. Results describe the crystal structure of visfatin in three different forms: apo and in complex with either nicotinamide mononucleotide (NMN) or the nicotinamide phosphoribosyltransferase inhibitor FK-866. PMID: 16901503
28. During fasting, increased Nampt provides protection against cell death and requires an intact mitochondrial NAD(+) salvage pathway as well as the mitochondrial NAD(+)-dependent deacetylases SIRT3 and SIRT4. PMID: 17889652
29. Visfatin is produced in mesangial cells, which are a novel target for visfatin, and play an important role in the pathogenesis of diabetic nephropathy. PMID: 18768589
30. improves insulin sensitivity and exerts its hypocholesterolemic effects at least partially through upregulation of the tyrosine phosphorylation of IRS-1 protein and the mRNA levels of PPARgamma and SREBP-2 PMID: 19263259
31. The crystal structure of rat visfatin in complex with IS001, is desribed. PMID: 19533035
32. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. PMID: 19661458
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亞細胞定位：

Nucleus. Cytoplasm. Secreted.
蛋白家族：

NAPRTase family
組織特異性：

Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung.
數(shù)據(jù)庫鏈接：

KEGG: rno:297508

STRING: 10116.ENSRNOP00000013043

UniGene: Rn.203508

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