NUSAP1 Antibody

說明書

中文名稱：

NUSAP1兔多克隆抗體
貨號：

CSB-PA222749
規格：

￥2024
圖片：
Western blot analysis of extracts from HT-29 cells, using NUSAP1 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NUSAP1 Polyclonal antibody
Uniprot No.：

Q9BXS6
基因名：

NUSAP1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human NUSAP1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.
基因功能參考文獻：
1. Study suggests that NUSAP1 might be involved in glioma progression and can serve as a prognosis biomarker for glioma patients. NUSAP1 silencing suppresses malignant phenotypes of glioma cells, which offer a theoretical foundation for further investigation of NUSAP1 as a possible target with advantages for glioma treatment. PMID: 29336114
2. NUSAP1 is overexpressed in colon cancer and high expression of NUSAP1 acts as an independent predictive factor for poor prognosis in colon cancer PMID: 29853313
3. Findings indicated that NUSAP1 played an important role in promoting aggressiveness in astrocytoma via activating the HH pathway. PMID: 28899410
4. our work provides a better understanding of the function of NUSAP1 in aggressive prostate cancers, provides rationale for using NUSAP1 as a prognostic biomarker, and sets the stage for developing improved therapeutic strategies for prostate and other cancers. PMID: 28404898
5. NUSAP1 contributes to accurate chromosome segregation by acting as a co-factor for RanBP2-RanGAP1-UBC9 during cell division. PMID: 28900032
6. NuSAP governs chromosome oscillation via regulation of Kid, facilitating the Kid-generated polar ejection force. Depletion of NuSAP significantly suppresses the amplitude and velocity of chromosome oscillation. PMID: 26839278
7. NUSAP1 may be a crucial biomarker for oral squamous cell carcinoma. down-regulated NUSAP1 expression suppresses tumor proliferation and also enhances anti-tumor effect of paclitaxel by activating apoptotic pathways. PMID: 26554377
8. High levels of NuSAP1 expression were related to poor disease-free survival, particularly in triple-negative breast cancer. PMID: 26485712
9. A novel association between BRCA1 and NUSAP1 is revealed and a mechanism whereby NUSAP1 is involved in carcinogenesis was elusidated. PMID: 24521615
10. High NUSAP1 expression is associated with cervical cancer. PMID: 23405241
11. NuSAP is a novel biomarker for prostate cancer recurrence after surgery and its overexpression appears to be driven in part by E2F1 activation PMID: 22349817
12. Phosphorylation of NuSAP by Cdk1 is an important mechanism to regulate microtubule dynamics during cell cycle progression. PMID: 22101338
13. Interphase NuSAP-chromatin interaction suggests additional functions for NuSAP, as recently identified for other nuclear spindle assembly factors with a role in gene expression or DNA damage response. PMID: 21782797
14. NuSAP1 is recognized as an immunogenic antigen in 65% of patients with AML following allogeneic HCT and suggests a tumor antigen role. PMID: 20053754
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亞細胞定位：

Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome.
蛋白家族：

NUSAP family
數據庫鏈接：

HGNC: 18538

OMIM: 612818

KEGG: hsa:51203

STRING: 9606.ENSP00000453403

UniGene: Hs.615092

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