NUP88 Antibody

說明書

中文名稱：

NUP88兔多克隆抗體
貨號：

CSB-PA004698
規格：

￥1090
圖片：
Western Blot analysis of K562 cells using Nup88 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q99567
基因名：

NUP88
別名：

88 kDa nucleoporin antibody; karyoporin antibody; Nuclear pore complex protein 88 antibody; Nuclear pore complex protein Nup88 antibody; Nuclear pore complex protein88 antibody; Nucleoporin 88 antibody; Nucleoporin 88 kDa antibody; Nucleoporin 88kDa antibody; Nucleoporin Nup88 antibody; Nucleoporin88 antibody; Nucleoporin88kDa antibody; Nup 84 antibody; NUP 88 antibody; Nup84 antibody; NUP88 antibody; NUP88_HUMAN antibody; Prei 2 antibody; Prei2 antibody; Preimplantation protein 2 antibody; Preimplantation protein2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human Nup88.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of nuclear pore complex.
基因功能參考文獻：
1. Overexpression of the NUP88 is associated with cancer. PMID: 27636375
2. Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions PMID: 26839161
3. These findings demonstrate that the NUP88-NUP98-RAE1-APC/CCDH1 axis contributes to aneuploidy PMID: 26731471
4. Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. PMID: 23777819
5. Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of colorectal cancer PMID: 21863385
6. Nup88 mRNA was overexpressed in colorectal cancers and the overexpression was associated with cancer development and aggressiveness. PMID: 21896994
7. Data suggest that a pool of Nup88 on the nuclear side of the nuclear pore complex provides a novel, unexpected binding site for nuclear lamin A. PMID: 21289091
8. association found between myometrial invasion and Nup88 expression in endometrial carcinoma PMID: 20973273
9. Gambogic acid exerts its anti-leukemia effects by regulating the expression and distribution of nucleoporin Nup88. PMID: 17828493
10. proper expression of Nup88 is critical for preventing aneuploidy formation and tumorigenesis. PMID: 20497554
11. High Nup88 mRNA expression levels correlated with ductal and tubular histology, nuclear grade 3, absence of hormone receptors, expression of c-erb-B2 oncogene and mutant p53 protein, high proliferation, DNA aneuploidy, and axillary node invasion. PMID: 14999780
12. A monoclonal antibody for Nup88 in an experimental model for studying the role played by Nup88 during cell development and differentiation. PMID: 15300515
13. the Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export PMID: 16675447
14. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. PMID: 17007055
15. The antitumor activity of deguelin was related to up-regulating the expression of Nup98 and down-regulating Nup88 protein. PMID: 17650673
16. The formation of high molecular mass complexes containing importin-alpha, Nup153 and Nup88 is increased upon oxidant treatment. PMID: 18068677
17. Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes. PMID: 18606815
18. Nup88 is significantly overexpressed in high-grade CIN lesions and ISCC compared with normal ectocervical squamous epithelia and CIN1. PMID: 19751906
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亞細胞定位：

Nucleus, nuclear pore complex.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 8067

OMIM: 602552

KEGG: hsa:4927

STRING: 9606.ENSP00000458954

UniGene: Hs.584784

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