NUP85 Antibody

中文名稱：

NUP85兔多克隆抗體
貨號(hào)：

CSB-PA874821LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HEK293 whole cell lysate, NIH/3T3 whole cell lysate, Mouse kidney tissue
All lanes: NUP85 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76, 53, 70 kDa
Observed band size: 76, 70 kDa

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA874821LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA874821LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA874821LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) NUP85 Polyclonal antibody
Uniprot No.：

Q9BW27
基因名：

NUP85
別名：

85 kDa nucleoporin antibody; FLJ12549 antibody; FROUNT antibody; Frount protein antibody; Nuclear pore complex protein nucleoporin 85 kDa antibody; nuclear pore complex protein nucleoporin Nup75 antibody; Nuclear pore complex protein Nup85 antibody; Nucleoporin 85 antibody; Nucleoporin 85kDa antibody; Nucleoporin nucleoporin 85kDa antibody; Nucleoporin Nup75 antibody; Nucleoporin NUP85 antibody; nucleoporin, 75-KD antibody; Nucleoporin85 antibody; Nup 75 antibody; NUP 85 antibody; Nup75 antibody; nup85 antibody; NUP85_HUMAN antibody; PCN antibody; PCNT 1 antibody; PCNT antibody; PCNT, formerly antibody; PCNT1 antibody; Pericentrin antibody; Pericentrin, formerly antibody; Pericentrin-1 antibody; Pericentrin1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Nuclear pore complex protein Nup85 protein (201-500AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，NUP85 Antibody (CSB-PA874821LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于NUP85 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA874821LB01HU	NUP85 Antibody, HRP conjugated	ELISA
FITC	CSB-PA874821LC01HU	NUP85 Antibody, FITC conjugated
Biotin	CSB-PA874821LD01HU	NUP85 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis.
基因功能參考文獻(xiàn)：
1. results support a model of CCR2 equilibrium: chemokine binding changes the conformational equilibrium of CCR2 toward the active state, and Pro-C switches its binding partner from the membrane to FROUNT PMID: 25283965
2. Residues on the hydrophobic side are completely conserved among FROUNT-binding receptors. PMID: 24128342
3. Data show that the C Terminus of Nup120 Directly Binds Nup145C and Nup85. PMID: 19576787
4. The CCL2/CCR2 pathway via FROUNT may influence the clinical severity of CHF. PMID: 17395051
5. FROUNT binds to the C-terminal domain of CCR5 in addition to that of CCR2. PMID: 19841162
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亞細(xì)胞定位：

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane.
蛋白家族：

Nucleoporin Nup85 family
數(shù)據(jù)庫鏈接：

HGNC: 8734

OMIM: 170285

KEGG: hsa:79902

STRING: 9606.ENSP00000245544

UniGene: Hs.362817

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