NUCKS1 Antibody

說明書

中文名稱：

NUCKS1兔多克隆抗體
貨號：

CSB-PA050060
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9H1E3
基因名：

NUCKS1
別名：

FLJ21480 antibody; FLJ32016 antibody; FLJ38536 antibody; JC7 antibody; NUCKS 1 antibody; NUCKS antibody; NUCKS_HUMAN antibody; Nucks1 antibody; Nuclear casein kinase and cyclin dependent kinase substrate 1 antibody; Nuclear ubiquitous casein and cyclin dependent kinases substrate antibody; Nuclear ubiquitous casein and cyclin-dependent kinases substrate antibody; Nuclear ubiquitous casein kinase and cyclin dependent kinase substrate antibody; P1 antibody; Potential LAG1 interactor antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human NUCKS.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.
基因功能參考文獻：
1. our results suggested that there was a significant association of a minor allele (G) in rs823114 with reduced risk of Parkinson's disease development (P = 0.017, OR = 0.768, 95%CI = 0.618 - 0.955). We conclude that NUCKS1 rs823114 indicates a decreased risk of susceptibility to Parkinson's disease and shows a male genetic distribution bias in the Han Chinese population. PMID: 29607885
2. High NUCKS1 expression is associated with drug resistance in lung cancer. PMID: 26989074
3. NUCKS overexpression had prognostic potential for overall survival and disease-free survival in advanced ovarian cancers and only for disease-free survival in early ovarian cancers . Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer PMID: 28877654
4. NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC PMID: 26968889
5. The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression. PMID: 26323318
6. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators. PMID: 24931609
7. NUCKS1 expression did not increase Tat nuclear localization. PMID: 25116364
8. NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma PMID: 24819170
9. NUCKS-1 overexpression is associated with obesity and with breast cancer. PMID: 24568505
10. We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67, thus allowing more precise assessment of tumor proliferation potential. PMID: 25119009
11. Authors suggest that NUCKS is involved in cellular responses following PDT. PMID: 24284105
12. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis. PMID: 24140890
13. Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer. PMID: 23065711
14. The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression. PMID: 19664271
15. Overexpression of NUCKS can play significant role in breast cancer biology. PMID: 20069058
16. Two putative nuclear localization signals have been identified and characterized in NUCKS. PMID: 17604136
17. NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described. PMID: 18491381
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亞細胞定位：

Nucleus. Chromosome.
組織特異性：

Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.
數據庫鏈接：

HGNC: 29923

OMIM: 611912

KEGG: hsa:64710

STRING: 9606.ENSP00000356110

UniGene: Hs.213061

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