NUB1 Antibody
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中文名稱：NUB1兔多克隆抗體
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貨號：CSB-PA016141GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：NUB1
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別名：BS4 antibody; NEDD8 ultimate buster 1 antibody; Negative regulator of ubiquitin like proteins 1 antibody; Negative regulator of ubiquitin-like proteins 1 antibody; NUB1 antibody; NUB1_HUMAN antibody; NUB1L antibody; NY REN 18 antibody; NYREN18 antibody; Renal carcinoma antigen NY-REN-18 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human NUB1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
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基因功能參考文獻(xiàn)：
- Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159. PMID: 28099510
- data suggest that NUB1 participates in telomere maintenance by regulating the levels of TRF1 at telomeres through both NEDD8-dependent and NEDD8-independent pathways. PMID: 27214791
- NUB1L suppresses atypical neddylation and promotes the degradation of misfolded proteins by the proteasome PMID: 26260793
- Based on biochemical features of the VBM motifs, we also identified NUB1L (NEDD8 ultimate buster-1 long) as a novel VBM-containing protein, which is involved in proteasomal degradation of NEDD8 through the P97 pathway. PMID: 24100225
- In coordination with the P97-UFD1-NPL4 complex (P97(UFD1/NPL4)), NUB1L promotes transfer of NEDD8 to proteasome for degradation. PMID: 24019527
- This study identified genes modifying endogenous mHTT using high-throughput screening and demonstrate NUB1 as an exemplar entry point for therapeutic intervention of Huntington's disease. PMID: 23525043
- Data propose that NUB1, by regulating GSK3beta levels, modulates tau phosphorylation and aggregation, and is a key player in neurodegeneration associated with tau pathology. PMID: 22965877
- In the present study, the proportions of intranuclear inclusion positive for NEDD8, NUB1 and SUMO-1 were significantly lower in glial cells than in neurons. PMID: 22612509
- The finding of this study suggested that NUB1 along with abnormal alpha-synuclein is involved in the pathogenesis of Lewy body disease. PMID: 21937912
- NUB1 has a splicing variant, NUB1L, which regulates the NEDD8 conjugation system PMID: 12816948
- These results imply that the ubiquitin precursor UbC1 hydrolysis mediated by NEDD8 ultimate buster-1 (NUB1) is involved in cellular functions in the seminiferous tubules such as spermatogenesis. PMID: 15009209
- NUB1L not only acts as a linker between the 26 S proteasome and ubiquitin-like proteins, but also as a facilitator of proteasomal degradation. PMID: 16707496
- These results suggest that NUB1 indeed targets synphilin-1 to the proteasome for its efficient degradation, which, because of the resultant reduction in synphilin-1, suppresses the formation of synphilin-1-positive inclusions. PMID: 16877356
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亞細(xì)胞定位：Nucleus. Note=Predominantly nuclear.
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組織特異性：Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
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數(shù)據(jù)庫鏈接：
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