NT5C3A Antibody

說明書

中文名稱：

NT5C3A兔多克隆抗體
貨號：

CSB-PA867122DSR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA867122DSR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA867122DSR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NT5C3A Polyclonal antibody
Uniprot No.：

Q9H0P0
基因名：

NT5C3A
別名：

5NT3A_HUMAN antibody; cN III antibody; cN-III antibody; cNIII antibody; Cytosolic 5' nucleotidase 3 antibody; Cytosolic 5' nucleotidase III antibody; Cytosolic 5''-nucleotidase 3 antibody; Cytosolic 5''-nucleotidase 3A antibody; Cytosolic 5''-nucleotidase III antibody; NT5C3 antibody; Nt5c3a antibody; p36 antibody; P5''N-1 antibody; P5'N 1 antibody; P5'N1 antibody; P5N 1 antibody; P5N-1 antibody; P5N1 antibody; PN I antibody; PN-I antibody; PNI antibody; PSN1 antibody; Pyrimidine 5' nucleotidase 1 antibody; Pyrimidine 5''-nucleotidase 1 antibody; UMPH antibody; UMPH1 antibody; Uridine 5' monophosphate hydrolase 1 antibody; Uridine 5''-monophosphate hydrolase 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cytosolic 5\'-nucleotidase 3A protein (37-336AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
基因功能參考文獻：
1. Results from a study on gene expression variability markers in early-stage human embryos shows that NT5C3A is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients PMID: 27381654
3. Pyrimidine-5'-nucleotidase Campinas is a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase type I deficiency. PMID: 25153905
4. Results show that NT5C3 expression levels were significantly increased in patients with risk allele homozygote. PMID: 25000516
5. New missense homozygous mutation (Q270Ter) in the pyrimidine 5' nucleotidase type I-related gene in two Indian families with hereditary non-spherocytic hemolytic anemia. PMID: 23139015
6. All investigated mutant proteins display impaired catalytic properties and/or reduced thermostability, providing a rationale for the pathological effects of the mutations. PMID: 15604219
7. These data highlight hUMP1/POMP role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system. PMID: 17349762
8. 3 newly described missense mutations (c.187T>C, c.469G>C & c.740T>C) identified in patients with hemolytic anemia were characterized at protein level; the enzymes were altered in both thermal stability and catalytic efficiency PMID: 18499901
9. genetic variation in NT5C3 might affect protein function and potentially influence drug response PMID: 19623099
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相關疾?。?/div>
P5N deficiency (P5ND)
亞細胞定位：

Cytoplasm.; [Isoform 2]: Endoplasmic reticulum.
蛋白家族：

Pyrimidine 5'-nucleotidase family
組織特異性：

Isoforms 1, 3 and 4 are expressed in reticulocytes. Isoform 4 is hardly detectable in bone marrow and fetal liver.
數據庫鏈接：

HGNC: 17820

OMIM: 266120

KEGG: hsa:51251

STRING: 9606.ENSP00000242210

UniGene: Hs.487933

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