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中文名稱：
NSFL1C兔多克隆抗體
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貨號：
CSB-PA892163DSR1HU
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規格：
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圖片：
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Western blot
All lanes: NSFL1C antibody at 6.3μg/ml
Lane 1: Mouse brain tissue
Lane 2: A431 whole cell lysate
Lane 3: 293T whole cell lysate
Lane 4: Rat liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 41, 38, 29 kDa
Observed band size: 41, 130 kDa
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892163DSR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA892163DSR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：
Rabbit anti-Homo sapiens (Human) NSFL1C Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：
DJ776F14.1 antibody; MGC3347 antibody; NSF1C_HUMAN antibody; NSFL1 (p97) cofactor (p47) antibody; NSFL1 cofactor p47 antibody; NSFL1C antibody; OTTHUMP00000029972 antibody; OTTHUMP00000029974 antibody; p47 antibody; P47 protein antibody; p97 cofactor p47 antibody; SHP1 homolog antibody; UBX domain protein 2C antibody; UBX domain-containing protein 2C antibody; UBX1 antibody; UBXD10 antibody; UBXN2C antibody
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宿主：
Rabbit
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反應種屬：
Human, Mouse, Rat
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免疫原：
Recombinant Human NSFL1 cofactor p47 protein (1-185AA)
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免疫原種屬：
Homo sapiens (Human)
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標記方式：
Non-conjugated
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克隆類型：
Polyclonal
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抗體亞型：
IgG
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純化方式：
Antigen Affinity Purified
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：
Liquid
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應用范圍：
ELISA, WB, IHC
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推薦稀釋比：
| Application |
Recommended Dilution |
| WB |
1:1000-1:5000 |
| IHC |
1:20-1:200 |
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Protocols：
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儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能：
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
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基因功能參考文獻：
- p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, alpha-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. PMID: 27785701
- The present results for the first time demonstrate that BDNF induces NADPH oxidase -derived reactive oxygen species generation through activation of p47 phox in a TrkB receptor-dependent manner PMID: 24612679
- human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A PMID: 23649807
- The binding of p47 to polyubiquitinated NEMO triggers the lysosomal degradation of NEMO, thereby inhibiting IKK activation. PMID: 22990857
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亞細胞定位：
Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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蛋白家族：
NSFL1C family
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數據庫鏈接：
Most popular with customers
Western blot
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892163DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA892163DSR1HU at dilution of 1:100
