NSF Antibody

說明書

中文名稱：

NSF兔多克隆抗體
貨號：

CSB-PA020159
規格：

￥1090
圖片：
Western Blot analysis of CoLo cells using NSF Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P46459
基因名：

NSF
別名：

N ethylmaleimide sensitive factor antibody; N ethylmaleimide sensitive factor like protein antibody; N ethylmaleimide sensitive fusion protein antibody; N-ethylmaleimide-sensitive fusion protein antibody; NEM sensitive fusion protein antibody; NEM-sensitive fusion protein antibody; NSF antibody; NSF_HUMAN antibody; SKD 2 antibody; SKD2 antibody; Vesicle fusing ATPase antibody; Vesicle-fusing ATPase antibody; Vesicular fusion protein NSF antibody; Vesicular-fusion protein NSF antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human NSF.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.
基因功能參考文獻：
1. A large copy number variant (CNV) that encompasses part of the NSF gene contributes to cocaine dependence. PMID: 27498889
2. NSF deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin endocytosis. PMID: 27995606
3. a processive helicase-like mechanism for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule. PMID: 23775070
4. Single and multiple-marker analyses revealed a strong association between cocaine dependence and the NSF gene. PMID: 21426264
5. Knockdown of TRX1 increases the level of S-nitrosylated NSF, prolongs the inhibition of exocytosis, and suppresses leukocyte PMID: 21324905
6. NSF independent fusion of Salmonella-containing late phagosomes with early endosomes. PMID: 20176016
7. analysis of human NSF possible binding mode to GABARAP and GATE-16 PMID: 19533740
8. binding of NSF to GluR2-containing AMPARs in stabilizing these receptors in the synaptic membrane and impeding their regulated endocytosis. PMID: 12011465
9. role of interaction with GluR2 in regulation of AMPA receptors by brain-derived neurotrophic factor PMID: 12130635
10. Nitric oxide regulates exocytosis by S-nitrosylation of NSF. PMID: 14567912
11. Expressing a biochemically defined NSF mutant that lacks ATPase activity results in a dramatic inhibition of stimulated mast cell exocytosis. PMID: 14607937
12. NSF dissociates the VAMP-2.SNAP-25.syntaxin 13 complex, but has no effect on the Hrs-containing complex. PMID: 14769786
13. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein PMID: 16461345
14. dual regulation on hbeta2AR trafficking and signaling by NSF through direct binding to cargo receptor and its ATPase activity. PMID: 17510209
15. Data show that NSF is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. PMID: 18836734
16. Data show that phosphorylation of N-ethylmaleimide-sensitive factor on tyrosine residues prevents its SNARE complex dissociation activity and establish a role for PTP1B in the modulation of the membrane fusion machinery. PMID: 19208619
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亞細胞定位：

Cytoplasm.
蛋白家族：

AAA ATPase family
數據庫鏈接：

HGNC: 8016

OMIM: 601633

KEGG: hsa:4905

STRING: 9606.ENSP00000381293

UniGene: Hs.431279

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