NREP Antibody

中文名稱：

NREP兔多克隆抗體
貨號：

CSB-PA620971LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA620971LA01HU diluted at 1:600 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system.

Immunofluorescence staining of SH-SY5Y cells with CSB-PA620971LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NREP Polyclonal antibody
Uniprot No.：

Q16612
基因名：

NREP
別名：

3.1 gene antibody; C5orf13 antibody; Chromosome 5 open reading frame 13 antibody; D4S114 antibody; Neuronal protein 3.1 antibody; Neuronal regeneration related protein antibody; Neuronal regeneration related protein homolog (rat) antibody; Neuronal regeneration related protein homolog antibody; NP311_HUMAN antibody; NREP antibody; P311 antibody; PRO1873 antibody; Protein p311 antibody; PTZ17 antibody; SEZ17 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Neuronal regeneration-related protein (1-68AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NREP Antibody (CSB-PA620971LA01HU)，的標記方式是Non-conjugated。對于NREP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA620971LB01HU	NREP Antibody, HRP conjugated	ELISA
FITC	CSB-PA620971LC01HU	NREP Antibody, FITC conjugated
Biotin	CSB-PA620971LD01HU	NREP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration. May also have functions in cellular differentiation. Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.
基因功能參考文獻：
1. P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing. PMID: 27906099
2. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation. PMID: 27927130
3. These studies demonstrate that P311 is required for the production of normal cutaneous scars PMID: 27939132
4. P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis. PMID: 26616407
5. P311 may promote the migration of ESCs both in micewith superficial partial-thickness burns and in an injured cell model in vitro, and it may play an important role in wound healing. PMID: 22967977
6. Protein HYI may closely bind with protein P311 by an alpha helix in hypertrophic scar fibroblasts. PMID: 22490543
7. P311 and ITGB4BP expression was elevated in non-small cell lung cancer, possibly indicative of a new signaling pathway. PMID: 21029697
8. P311 may be involved in the pathogenesis of hypertrophic scar via induction of a myofibrobla PMID: 20404911
9. role for P311 in inducing TGF-beta1-independent myofibroblast transformation PMID: 12417574
10. These results suggest a role for levels of P311 in regulating glioma motility and invasion through the reorganization of actin cytoskeleton at the cell periphery. PMID: 16229809
11. P311 expression is tightly regulated during the critical periods of alveolar formation, and that under pathologic conditions, its relative absence may contribute to failure of alveolar regeneration and lead to the development of human emphysema. PMID: 16484684
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亞細胞定位：

Cytoplasm.
組織特異性：

Expressed in lung (at protein level).
數據庫鏈接：

HGNC: 16834

OMIM: 607332

KEGG: hsa:9315

UniGene: Hs.36053

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