NRBP1 Antibody

說明書

中文名稱：

NRBP1兔多克隆抗體
貨號：

CSB-PA883410ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: NRBP1 antibody at 1.99µg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 60 kDa
Observed band size: 60 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883410ESR2HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NRBP1 Polyclonal antibody
Uniprot No.：

Q9UHY1
基因名：

NRBP1
別名：

BCON3 antibody; MADM antibody; MUDPNP antibody; Multiple domain putative nuclear protein antibody; Myeloid leukemia factor 1 adaptor molecule antibody; NRBP antibody; NRBP_HUMAN antibody; NRBP1 antibody; Nuclear receptor binding protein antibody; Nuclear receptor-binding protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nuclear receptor-binding protein (406-535AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
基因功能參考文獻：
1. Study have identified a gout risk gene, NRBP1,and demonstrated that increased NRBP1 expression in gout patients may be regulated through methylation-dependent binding of TFAP2A to the B1 region, a 72 bp upstream of NRBP1 transcription start site. PMID: 28932319
2. The present study deals with the molecular modeling of the viral protein (NS3 of DENV1-4), the host protein (NRBP) and their interactions through protein-protein docking study. PMID: 24910013
3. Targeting this we performed homology modeling and protein-protein docking study of NS3 with NRBP (Nuclear Receptor Binding Protein) of human as it has been proved that NS3 of DENV interacts with NRBP which causes cellular trafficking in human cell. PMID: 24372240
4. High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth. PMID: 22473923
5. It was shown that NRBP1 is a tumour suppressor that plays a critical role in intestinal cell homoeostasis. NRBP1 levels are reduced in a wide variety of human tumours. Reduced NRBP1 levels in lung cancer correlates with a poor prognosis. PMID: 22510880
6. Interaction of the small GTPase Rac3 with NRBP: results suggest that NRBP functions in subcellular trafficking and may be directed to specific subcellular locations through interaction with small GTPases of the Rho family PMID: 11956649
7. mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1 PMID: 12176995
8. NS3 protein of dengue virus type 2 interacted specifically with nuclear receptor binding protein, a host cellular protein that influences trafficking between the endoplasmic reticulum and Golgi, and that interacts with Rac3 PMID: 15084397
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亞細胞定位：

Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
組織特異性：

Ubiquitously expressed in all tissues examined with high levels in the testis.
數據庫鏈接：

HGNC: 7993

OMIM: 606010

KEGG: hsa:29959

STRING: 9606.ENSP00000233557

UniGene: Hs.515876

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