NOSTRIN Antibody

中文名稱：

NOSTRIN兔多克隆抗體
貨號：

CSB-PA818236LA01HU
規格：

￥440
圖片：
Western blot
All lanes: NOSTRIN antibody at 6µg/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58, 55, 49, 65 kDa
Observed band size: 58 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA818236LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA818236LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NOSTRIN Polyclonal antibody
Uniprot No.：

Q8IVI9
基因名：

NOSTRIN
別名：

BM247 antibody; BM247 homolog antibody; DaIP2 antibody; eNOS-trafficking inducer antibody; mDaIP2 antibody; MGC20702 antibody; Nitric oxide synthase traffic inducer antibody; Nitric oxide synthase trafficker antibody; NOSTN_HUMAN antibody; Nostrin antibody; RP23-431D4.2 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Nostrin protein (1-322AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NOSTRIN Antibody (CSB-PA818236LA01HU)，的標記方式是Non-conjugated。對于NOSTRIN Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA818236LB01HU	NOSTRIN Antibody, HRP conjugated	ELISA
FITC	CSB-PA818236LC01HU	NOSTRIN Antibody, FITC conjugated
Biotin	CSB-PA818236LD01HU	NOSTRIN Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
基因功能參考文獻：
1. The suggest that scores obtained with the worst nostril are the most efficient in detecting an olfactory disorder. PMID: 28981819
2. NOSTRIN inhibited production of nitric oxide (NO) by suppressing the activation of endothelial nitric oxide synthase (eNOS). PMID: 27401251
3. no significant difference in serum level associated with preeclampsia or intrauterine growth restriction PMID: 24588201
4. This study showed that overexpression of NOSTRIN had a significant effect on eNOS activity in HUVECs and resulted in significant cellular damage. PMID: 23592143
5. The expression of NOSTRIN is decreased, while the activity of eNOS and the level of NO2-/NO3- increased in the testis tissue of azoospermia patients. PMID: 21351530
6. Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN. PMID: 21183735
7. NOSTRIN expression was increased in umbilical vessel of women with pre-eclampsia. PMID: 19399414
8. NOSTRIN modulates nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. PMID: 12446846
9. NOSTRIN may facilitate endocytosis of endothelial nitric oxide synthase by coordinating the function of dynamin and the actin nucleation promoting factor N-WASP. PMID: 16234328
10. A ternary complex between NOSTRIN, caveolin-1, and eNOS mediates translocation of eNOS, with important implications for the activity and availability of eNOS in the cell. PMID: 16807357
11. results suggest that nuclear NOSTRINbeta may negatively regulate transcription of the NOSTRIN gene PMID: 18980613
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亞細胞定位：

[Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus.
組織特異性：

Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
數據庫鏈接：

HGNC: 20203

OMIM: 607496

KEGG: hsa:115677

UniGene: Hs.189780

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