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中文名稱：
NOC2L兔多克隆抗體
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貨號：
CSB-PA115442
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規格：
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA115442(NOC2L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA115442(NOC2L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA115442(NOC2L Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：
NOC2L
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別名：
NET15 antibody; NET7 antibody; NIR antibody; NOC2 like antibody; NOC2 like nucleolar associated transcriptional repressor antibody; NOC2-like protein antibody; NOC2L antibody; NOC2L nucleolar associated transcriptional repressor antibody; NOC2L_HUMAN antibody; Novel INHAT (inhibitor of histone acetyltransferase) repressor antibody; Novel INHAT repressor antibody; Nucleolar complex associated 2 homolog (S. cerevisiae) antibody; Nucleolar complex protein 2 homolog antibody; PPP1R112 antibody; Protein NOC2 homolog antibody; Protein phosphatase 1 regulatory subunit 12 antibody
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宿主：
Rabbit
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反應種屬：
Human,Mouse
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免疫原：
Fusion protein of Human NOC2L
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免疫原種屬：
Homo sapiens (Human)
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標記方式：
Non-conjugated
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抗體亞型：
IgG
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純化方式：
Antigen affinity purification
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：
Liquid
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應用范圍：
ELISA,WB,IHC
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推薦稀釋比：
| Application |
Recommended Dilution |
| ELISA |
1:1000-1:2000 |
| WB |
1:200-1:1000 |
| IHC |
1:25-1:100 |
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Protocols：
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儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能：
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
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基因功能參考文獻：
- A transcriptional repressor NIR functions in the rRNA biogenesis of both the 40S and 60S subunits. PMID: 22363708
- Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. PMID: 20959462
- Upon recruitment by p53, NIR represses transcription of both p53-dependent reporters and endogenous target genes PMID: 16322561
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亞細胞定位：
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
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蛋白家族：
NOC2 family
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數據庫鏈接：
Most popular with customers
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA115442(NOC2L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA115442(NOC2L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA115442(NOC2L Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
