NLGN3 Antibody, Biotin conjugated
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中文名稱：NLGN3兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA873703LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NLGN3 Polyclonal antibody
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Uniprot No.：
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基因名：NLGN3
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別名：Gliotactin homolog antibody; HNL3 antibody; Neuroligin-3 antibody; Nlgn3 antibody; NLGN3_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Neuroligin-3 protein (642-783AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
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基因功能參考文獻：
- Wnt/beta-catenin signaling targets the trasncription of the autism-associated Neuroligin 3 gene. PMID: 29503438
- NLGN3 protects retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs) from H2O2. PMID: 29792861
- Our data suggest that these four previously described neuroligin mutations are not primary risk factors for autism. PMID: 28948087
- high-grade gliomas growth depends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion PMID: 28959975
- e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. PMID: 27805570
- No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis. PMID: 27782075
- The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation. PMID: 25913192
- Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population. PMID: 24570023
- The present study explores, for the first time, the contribution of NLGN3 and NLGN4X genetic variants in Greek patients with autistic disorder. PMID: 23851596
- Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PMID: 23468870
- Neuroligins are adhesion proteins that bind to beta-neurexin to form functional synapses. PMID: 23431752
- Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1. PMID: 22671294
- study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population. PMID: 21569590
- further characterization of the R451C mutation in NLGN3;role in protein folding PMID: 20227402
- report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders PMID: 12669065
- No structural variants were found in the NLGN3 gene when 96 unrelated patients with autism, 24 ADHD and 24 bipolar disorder patients were analyzed. PMID: 15622415
- Neuroligin mutations most probably represent rare causes of autism; it is unlikely that the allelic variants in any of these genes would be major risk factors for autism. PMID: 16077734
- Data indicate that coding mutations in neuroligin 3 are very rarely associated to autism spectrum disorders. PMID: 16508939
- Splice variants of the NLGN3 gene are associated with autism. PMID: 16648374
- Syntrophin-gamma2 (SNTG2) is a de novo binding partner of neuroligin 3, which correlates with autism-related mutations. PMID: 17292328
- no evidence for an involvement of NLGN3 and NLGN4X genetic variants with autism spectrum disorder on high functioning level PMID: 18189281
- these data support the hypothesis that the autism-associated NL3 mutation affects information processing in neuronal networks by altering network architecture and synchrony PMID: 19406211
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相關疾病：Autism, X-linked 1 (AUTSX1); Asperger syndrome, X-linked, 1 (ASPGX1)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
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蛋白家族：Type-B carboxylesterase/lipase family
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組織特異性：Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
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數據庫鏈接：
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