NKRF Antibody
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中文名稱：NKRF兔多克隆抗體
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貨號：CSB-PA015836GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：NKRF
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別名：NKRF antibody; ITBA4 antibody; NRF antibody; NF-kappa-B-repressing factor antibody; NFkB-repressing factor antibody; Protein ITBA4 antibody; Transcription factor NRF antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NKRF
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
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基因功能參考文獻：
- NKRF is a nucleolar HSP essential for nucleolus homeostasis and cell survival under proteotoxic stress. NKRF is a thermosensor translocating from the nucleolus to the nucleoplasm during heat stress; nucleolar pools are replenished upon HSF1-mediated NKRF resynthesis. NKRF is an unconventional HSP crucial for correct rRNA processing. Under stress conditions, NKRF directs XRN2 nucleolus/nucleoplasm trafficking. PMID: 28096332
- Data suggest that L protein from LCMV interactions with host proteome, specifically DDX3X, NKRF, and TRIM21. (LCMV = Lymphocytic choriomeningitis mammarenavirus; DDX3X = DEAD-box helicase 3; NKRF = NF-kappa-B-repressing factor; TRIM21 = tripartite motif-containing protein-21) PMID: 29261807
- depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
- NF-kappaB-repressing factor (NKRF) phosphorylation modulates promoter-proximal transcription elongation of NF-kappaB/NKRF-regulated genes via direct interactions with elongation complex in response to specific stimuli PMID: 26340924
- The up-regulated NKRF serves as an endogenous repressor for IP-10 and IL-8 synthesis to hinder host from robust response to MTb infection. PMID: 25135111
- MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. PMID: 25277410
- NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 and IL-8/CXCL8 when TB bacterial load is high. PMID: 24223729
- The expression of NKRF is decreased in PBMCs of patients with stable COPD. The downregulation of NKRF was found to be closely related to enhanced IL-8 production from these peripheral blood cells through de-repression of the IL-8 promoter. PMID: 22441735
- The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs. PMID: 21300069
- role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene PMID: 12381793
- cDNA is 3247 bp long, contains three exons and maps to human chromosome Xq24. NRF is widely expressed in human tissues. PMID: 14744032
- Full-length NRF is highly enriched in nucleoli and only a small fraction of NRF is found in the nucleoplasm and cytoplasm PMID: 15226370
- NRF interrupts the regulatory coupling of LTR binding factors and transcription elongation events; this inhibitory mechanism might contribute to transcriptional quiescence of integrated HIV-1 provirus PMID: 16107696
- Induction of MMP-9 gene expression is regulated by oscillatory/cumulative activation of NFkappaB in a colon cancer cell line. PMID: 17186550
- The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity. PMID: 17592041
- saimiri transformation-associated protein of subgroup C induces NF-kappaB activation PMID: 18560378
- Induction of NRF in human airway smooth muscle cells by neutrophil elastase mediates the suppression of interleukin (IL)-8/CXCL8 expression. PMID: 19542452
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亞細胞定位：Nucleus, nucleolus.
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組織特異性：Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
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