NIN Antibody, Biotin conjugated

說明書

中文名稱：

NIN兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA843155LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NIN Polyclonal antibody
Uniprot No.：

Q8N4C6
基因名：

NIN
別名：

Centrosome Marker antibody; Glycogen synthase kinase 3 beta interacting protein antibody; GSK3B interacting protein antibody; h Glycogen synthase kinase 3 beta-interacting protein antibody; hNinein antibody; KIAA1565 antibody; NIN antibody; NIN protein antibody; NIN_HUMAN antibody; ninein (GSK3B interacting protein) antibody; Ninein antibody; Ninein centrosomal protein antibody; SCKL7 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ninein protein (80-185AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.
基因功能參考文獻：
1. Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage. PMID: 22937743
2. Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics. PMID: 25741725
3. JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it PMID: 25332239
4. A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. PMID: 23665482
5. The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells PMID: 23047184
6. The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera. PMID: 21667027
7. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
8. Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk PMID: 20056645
9. Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. PMID: 11956314
10. ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle PMID: 12927815
11. Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation. PMID: 15190203
12. We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. PMID: 15784680
13. our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus PMID: 16154161
14. analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin PMID: 17102634
15. hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity. PMID: 17383637
16. Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. PMID: 17698918
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相關疾病：

Seckel syndrome 7 (SCKL7)
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.; [Isoform 6]: Cytoplasm.
組織特異性：

Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.
數據庫鏈接：

HGNC: 14906

OMIM: 608684

KEGG: hsa:51199

STRING: 9606.ENSP00000371472

UniGene: Hs.310429

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