NID1 Antibody

中文名稱：

NID1兔多克隆抗體
貨號：

CSB-PA015802LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA015802LA01HU diluted at 1:200 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NID1 Polyclonal antibody
Uniprot No.：

P14543
基因名：

NID1
別名：

Enactin antibody; Ent antibody; Entactin 1 antibody; Entactin antibody; NID 1 antibody; NID antibody; NID-1 antibody; Nid1 antibody; NID1_HUMAN antibody; Nidogen (enactin) antibody; Nidogen 1 antibody; Nidogen antibody; Nidogen-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nidogen-1 protein (792-942AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NID1 Antibody (CSB-PA015802LA01HU)，的標記方式是Non-conjugated。對于NID1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA015802LB01HU	NID1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA015802LC01HU	NID1 Antibody, FITC conjugated
Biotin	CSB-PA015802LD01HU	NID1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
基因功能參考文獻：
1. Results demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The study presents evidence that NID1 promotes the migration, invasion and chemoresistance of ovarian cancer cells via EMT and its molecular mechanism involves the activation of ERK/MAPK signaling. PMID: 28416770
2. Nidogen 1 (NID1) was confirmed to promote lung metastasis of breast cancer and melanoma. PMID: 28827399
3. nidogen-1 degraded by CatS can be quantified in serum by the NIC assay. The current data strongly suggest that cathepsin-S degradation of nidogen-1 is strongly associated with NSCLC, which needs validation in larger clinical cohorts. PMID: 28282545
4. Differential protein expression of collagen IV, laminin alpha2, and nidogen-1 indicated basal lamina remodeling develops in ischemic failing versus nonfailing human hearts. PMID: 26756417
5. NID1 was confirmed as a target gene of MiR-192/215 in Hirschsprung's disease patients. PMID: 25857602
6. Increase of NID1 protein expression is associated with endometrial cancer invasion. PMID: 25924802
7. The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. PMID: 23681936
8. results demonstrate that mutation in either NID1 or LAMC1 disrupts the interaction NID1-LAMC1 complex; findings implicate the extracellular matrix in the pathogenesis of Dandy-Walker spectrum disorders PMID: 23674478
9. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners PMID: 22952693
10. NID1 gene is a biologically plausible locus for nevogenesis and melanoma development PMID: 21478494
11. found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development PMID: 12005023
12. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
13. CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. PMID: 17328794
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亞細胞定位：

Secreted, extracellular space, extracellular matrix, basement membrane.
數據庫鏈接：

HGNC: 7821

OMIM: 131390

KEGG: hsa:4811

STRING: 9606.ENSP00000264187

UniGene: Hs.356624

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