NHP2 Antibody

中文名稱：

NHP2兔多克隆抗體
貨號：

CSB-PA873677LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA873677LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA873677LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NHP2 Polyclonal antibody
Uniprot No.：

Q9NX24
基因名：

NHP2
別名：

DKCB2 antibody; FLJ20479 antibody; H/ACA ribonucleoprotein complex subunit 2 antibody; NHP2 antibody; NHP2 like protein antibody; NHP2 ribonucleoprotein antibody; NHP2 ribonucleoprotein homolog (yeast) 1 antibody; NHP2 ribonucleoprotein homolog antibody; NHP2; S. cerevisiae; homolog of antibody; NHP2_HUMAN antibody; NHP2P antibody; NOLA2 antibody; Nucleolar protein family A member 2 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 2 antibody; snoRNP protein NHP2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human H/ACA ribonucleoprotein complex subunit 2 protein (1-153AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NHP2 Antibody (CSB-PA873677LA01HU)，的標記方式是Non-conjugated。對于NHP2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA873677LB01HU	NHP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873677LC01HU	NHP2 Antibody, FITC conjugated
Biotin	CSB-PA873677LD01HU	NHP2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
基因功能參考文獻：
1. In this work, we have uncovered a putative role of epigenetic regulation in a subset of human snoRNP complexes that are involved in the site-specific modification of RNA. We find that a subset of box C/D snoRNAs are methylated at the 1n position and that this blocks both 15.5k binding and the formation of the kinked conformation in vivo. PMID: 28623187
2. Indian aplastic anemia patients did not have NHP2 mutations. PMID: 25906515
3. Effects of dyskeratosis congenita mutations in NHP2 on assembly of H/ACA pre-RNPs PMID: 20008900
4. NOLA2 expression in patients with squamous cell lung cancer increased by 70% which makes it a highly informative marker of squamous cell lung cancer PMID: 15889794
5. The analysis of two other proteins, NHP2 and GAR1, that together with dyskerin and NOP10 are key components of telomerase and small nucleolar ribonucleoprotein (snoRNP) complexes, is described. PMID: 18523010
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相關疾病：

Dyskeratosis congenita, autosomal recessive, 2 (DKCB2)
亞細胞定位：

Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
蛋白家族：

Eukaryotic ribosomal protein eL8 family
組織特異性：

Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
數據庫鏈接：

HGNC: 14377

OMIM: 606470

KEGG: hsa:55651

STRING: 9606.ENSP00000274606

UniGene: Hs.744074

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