NFYC Antibody

說明書

中文名稱：

NFYC兔多克隆抗體
貨號：

CSB-PA003427
規格：

￥1090
圖片：
Western Blot analysis of 293 cells using NF-YC Polyclonal Antibody

Western Blot analysis of NIH-3T3 cells using NF-YC Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q13952
基因名：

NFYC
別名：

CAAT box DNA binding protein subunit C antibody; CAAT box DNA-binding protein subunit C antibody; CBF C antibody; CBFC antibody; CCAAT binding factor subunit C antibody; CCAAT transcription binding factor subunit gamma antibody; DKFZp667G242 antibody; FLJ45775 antibody; H1TF2A antibody; HAP5 antibody; histone H1 transcription factor large subunit 2A antibody; HSM antibody; NF-YC antibody; NFYC antibody; NFYC_HUMAN antibody; Nuclear transcription factor Y gamma antibody; Nuclear transcription factor Y subunit C antibody; Nuclear transcription factor Y subunit gamma antibody; OTTHUMP00000009207 antibody; OTTHUMP00000009208 antibody; OTTHUMP00000009209 antibody; OTTHUMP00000009210 antibody; OTTHUMP00000009211 antibody; OTTHUMP00000009212 antibody; OTTHUMP00000009213 antibody; OTTHUMP00000009215 antibody; OTTHUMP00000009217 antibody; OTTHUMP00000231028 antibody; Transactivator HSM 1/2 antibody; transactivator HSM-1 antibody; Transactivator HSM-1/2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human NF-YC.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
基因功能參考文獻：
1. NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival. PMID: 27495011
2. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
4. the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired. PMID: 23657974
5. NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease PMID: 22104449
6. Sp1, NF-Y and FOXO transcription factors are involved in the regulation of LKB1 transcription. PMID: 22412893
7. NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor via alteration of aldosterone-induced MR conformation PMID: 20054001
8. role in repressing Smad2 and Smad3 transactivating activity PMID: 12023901
9. C/EBPbeta contributes to the induction of hepatocyte replication in response to HGF in rodents, which is likely due to post-translational modifications. PMID: 15922473
10. Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple neoplasms. PMID: 19559782
11. NF-YC complexity is generated by dual promoters and alternative splicing PMID: 19690168
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亞細胞定位：

Nucleus.
蛋白家族：

NFYC/HAP5 subunit family
數據庫鏈接：

HGNC: 7806

OMIM: 605344

KEGG: hsa:4802

STRING: 9606.ENSP00000396620

UniGene: Hs.713051

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