NFIC Antibody

中文名稱：

NFIC兔多克隆抗體
貨號：

CSB-PA015756LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA015756LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA015756LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NFIC Polyclonal antibody
Uniprot No.：

P08651
基因名：

NFIC
別名：

1110019L22Rik antibody; 1500041O16Rik antibody; AA589446 antibody; AI746521 antibody; CAAT box transcription factor antibody; CCAAT binding transcription factor antibody; CCAAT box binding transcription factor antibody; CCAAT-box-binding transcription factor antibody; CNFI C antibody; CTF antibody; CTF5 antibody; MGC137374 antibody; MGC20153 antibody; NF I antibody; NF I/C antibody; NF-I/C antibody; NF1 C antibody; NF1-C antibody; NF1C antibody; NFI antibody; NFI-C antibody; NFI/C antibody; NFIC antibody; NFIC_HUMAN antibody; Nuclear factor 1 antibody; Nuclear factor 1 C type antibody; Nuclear factor 1 C-type antibody; Nuclear factor 1/C antibody; Nuclear factor I/C (CCAAT binding transcription factor) antibody; Nuclear factor I/C antibody; TGGCA binding protein antibody; TGGCA-binding protein antibody; Transcription factor NFIC antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nuclear factor 1 C-type protein (201-428AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NFIC Antibody (CSB-PA015756LA01HU)，的標記方式是Non-conjugated。對于NFIC Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA015756LB01HU	NFIC Antibody, HRP conjugated	ELISA
FITC	CSB-PA015756LC01HU	NFIC Antibody, FITC conjugated
Biotin	CSB-PA015756LD01HU	NFIC Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
基因功能參考文獻：
1. Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for the interaction of the (apolipoprotein E) APOE epsilon4 allele with NFIC SNP. PMID: 28183528
2. Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer PMID: 25879941
3. Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. PMID: 24801901
4. Over-expression of NFIC increased cell proliferation, mineralization nodule formation and alkaline phosphatase activity in stem cells from the apical papilla. PMID: 25668322
5. transcription factor Nuclear Factor 1-C (NF1C) as a candidate to regulate AHR transcription in a polymorphism-dependent manner PMID: 23208493
6. These data suggest a critical role for calcineurin in NFI transcriptional regulation and in the determination of malignant glioma infiltrative properties. PMID: 23839947
7. the influence of i3T3 on the expression and DNA binding of NFI, another TF important for cell proliferation and cell cycle progression PMID: 22420942
8. novel role of NF1-C2 in tumor development and epithelial-to-mesenchymal transition in breast cancer; NF1-C2 is lost during tumor progression and virtully absent from lymph node metastases; FoxF1 was was found to be a direct repressed target of NF1-C2 PMID: 20145151
9. A specific region (-688 to -611 bp) was discovered in the IRS2 promoter essential for basal promoter activity and oxidative stress induced transcription depending on ERK activation and SP1 and NFI binding in human hepatocytes. PMID: 19755487
10. diminished NF-1C-dependent repression may be one mechanism underlying increased basal CYP17 promoter activity and altered gene expression in PCOS (polycystic ovary syndrome) theca cells. PMID: 14684846
11. The BAF complex & NF1/CTF might act as components of the RNAP II holoenzyme to participate in formation of transcriptional pre-initiation complex. PMID: 15999204
12. Data demonstrate that nuclear Jak2 regulates the amount of active NF1-C2 through tyrosine phosphorylation and proteasomal degradation. PMID: 16847321
13. the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1 PMID: 17186943
14. we suggest that bHLH factors recruit NFI to enhance skeletal muscle Na(+) channel expression. PMID: 17936922
15. All NFI isoforms were found to be expressed in human corneal epithelial cells grown on laminin. PMID: 18421093
16. These are the first studies to analyze the expression of NFI-C isoforms in dental versus nondental cells/tissues. PMID: 18765927
17. These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells. PMID: 18775869
18. These results imply a central role of NFI-C in the interplay of the two signaling pathways and in regulation of the progression of tissue regeneration. PMID: 19752192
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亞細胞定位：

Nucleus.
蛋白家族：

CTF/NF-I family
數據庫鏈接：

HGNC: 7786

OMIM: 600729

KEGG: hsa:4782

STRING: 9606.ENSP00000465655

UniGene: Hs.170131

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