NFIB Antibody
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中文名稱：NFIB兔多克隆抗體
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貨號：CSB-PA015755GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：NFIB
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別名：CCAAT Box Binding Transcription Factor antibody; CCAAT-box-binding transcription factor antibody; CTF antibody; HMGIC/NFIB antibody; NF-I/B antibody; NF1-B antibody; NF1B antibody; NF1B2 antibody; NFI-B antibody; NFI-RED antibody; Nfib antibody; NFIB_HUMAN antibody; NFIB2 antibody; NFIB3 antibody; Nuclear factor 1 B-type antibody; Nuclear factor 1/B antibody; Nuclear Factor 1B antibody; Nuclear Factor I B antibody; Nuclear factor I/B antibody; TGGCA Binding Protein antibody; TGGCA-binding protein antibody; TRANSCRIPTION FACTOR NFIB antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NFIB
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
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基因功能參考文獻：
- High NF1B expression is associated with cell growth, aggressiveness, metastasis in gastric cancer. PMID: 30015981
- Studied role of miR-30d in tumor invasiveness and migration in non-small lung cancer (NSCLC). Found miR-30d suppressed cell migration and invasion by directly targeting nuclear factor I B (NFIB) in NSCLC. PMID: 28861760
- Study highlighted the paradoxical involvement of NFIB in both the inhibition and promotion of tumor development as well as progression in different malignancies; especially between different tumor subtypes within a single organ system, such as in lung, brain and skin,which corroborates its diverse and distinct roles in specific tissues and cell types. [review] PMID: 28596133
- we report that the transcription factor NFIB is associated with significantly improved survival in glioblastoma PMID: 27083054
- High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population. PMID: 27373156
- low expression of NFIB was significantly associated with biologically more aggressive subtypes and, ultimately, poorer survival in lung adenocarcinoma patients PMID: 27357447
- Data indicate that NFIB protein increases EZH2 protein expression downstream of BRN2 protein, which further decreases MITF protein levels. PMID: 28119061
- In benign prostatic hyperplasia, luminal NFIB loss correlated with more severe disease. in androgen-dependent LNCaP prostate cancer cells demonstrated that 64.3% of NFIB binding sites are associated with AR and FOXA1 binding sites. PMID: 26677878
- These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene. PMID: 26084801
- Further studies also discovered a conserved feedback regulatory circuitry formed by NFIB and miR-365 in cutaneous squamous cell carcinoma development PMID: 24949940
- multivariate analysis co-overexpression of NFIB, RANK and RANKL significantly increased the risk of metastasis with an odds ratio of 13.59 PMID: 25764026
- Increased expression of NF1B is associated with pilocytic astrocytoma. PMID: 23161775
- The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity. PMID: 22180456
- Tissue microarray results from invasive breast cancer patients, and the immunohistochemistry results showed a significant association between NFIB expression and nuclear grade, estrogen receptor, and HER2 expression status. PMID: 21925980
- study revealed that miRNA (miRs-372/373) can promote HBV expression through a pathway involving the transcription factor PMID: 21608007
- Functional studies indicate that NFIB regulates cell viability and proliferation during transformation PMID: 21764851
- these results suggest that NFIB is a novel and specific biomarker for oxaliplatin resistance in human cancers PMID: 21087353
- The the MYB-NFIB fusion characterizes a subset of ACCs and contributes to MYB overexpression. PMID: 20702610
- expression of NFI-B2 impairs CD4 transcription on CDd4-positive primary T-lymphocytes and cell lines in HIV-1 infection PMID: 12639247
- C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in tumor cells PMID: 17511965
- the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas PMID: 18663748
- Knockdown of NFIB and NFIC expression using siRNA decreased and increased IGFBP5 expression, respectively. PMID: 18809517
- lipomas containing NFIB rearrangements may be related to peculiar clinicohistologic features, including large size, deep situation, infiltration of surrounding muscles, or precocious occurrence. PMID: 19837271
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亞細胞定位：Nucleus.
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蛋白家族：CTF/NF-I family
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