NFIA Antibody

說明書

中文名稱：

NFIA兔多克隆抗體
貨號：

CSB-PA015754GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q12857
基因名：

NFIA
別名：

1110047K16Rik antibody; 9430022M17Rik antibody; CCAAT Box Binding Transcription Factor antibody; CCAAT-box-binding transcription factor antibody; CTF antibody; FLJ39164 antibody; NF I/A antibody; NF-I/A antibody; NF1-A antibody; NFI A antibody; NFI L antibody; NFI-A antibody; NFIA antibody; NFIA_HUMAN antibody; Nuclear factor 1 A type antibody; Nuclear factor 1 A-type antibody; Nuclear factor 1/A antibody; Nuclear factor I/A antibody; TGGCA binding protein antibody; TGGCA-binding protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human NFIA
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
基因功能參考文獻：
1. The consistent overlap in clinical presentation provides further evidence of the critical role of NFIA haploinsufficiency in the development of the 1p32-p31 microdeletion syndrome phenotype. PMID: 28941020
2. Data define a previously unknown nuclear factor I-A-nuclear factor-kappaB feed-forward regulation that may contribute to glioblastoma cell survival. PMID: 27994064
3. Studies indicate the role of nuclear factor one (NFIs) as epigenetic regulators in cancer. PMID: 28076901
4. Altogether, these results demonstrated that miR-370 suppressed hepatitis B virus gene expression and replication through repressing NFIA expression, which stimulates hepatitis B virus replication via direct regulation on hepatitis B virus Enhancer I activities. PMID: 27664977
5. We verified that NFIA binds to the IGFBP2 promoter and transcriptionally enhances IGFBP2 expression levels. We identified that NFIA-mediated IGFBP2 signaling pathways are involved in miR-302b-induced glioma cell death. PMID: 28323865
6. miR-191 was upregulated in patients with middle- and late-stage NSCLC, and in NSCLC cell lines, under mild hypoxic conditions. miR-191 promoted the proliferation and migration of NSCLC under chronic hypoxic conditions, and this promotion may be associated with its targeting of NFIA. PMID: 28075452
7. Dihydrocapsaicin can significantly decrease proinflammatory cytokines through enhancing NFIA and inhibiting NF-kappaB expression PMID: 27267730
8. These results demonstrated that RP5833A20.1 inhibited tumor cell proliferation, induced apoptosis and inhibited cellcycle progression by suppressing the expression of NFIA in U251 cells. PMID: 27779670
9. NFI-A is involved in the miR-21-induced expression of IL-10 in B cells in nasopharyngeal carcinoma; Il-10 is capable of suppressing CD8+ T-cell activities. PMID: 25544502
10. microRNA-136 targeted and degraded NFIA, which induced the release of microRNA-223, promoting CD11b expression. Direct base pairing occurs between miR-136 and the 3' UTR of NFIA mRNA. PMID: 26329426
11. this family also carried a microdeletion affecting solely the NFIA gene, this study substantiates the importance of this gene in craniofacial development. PMID: 25714559
12. TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence. PMID: 25220407
13. a strong candidate gene for asthma and allergic rhinitis PMID: 24560411
14. RP5-833A20.1/miR-382-5p/NFIA pathway was essential to the regulation of cholesterol homeostasis and inflammatory reactions. PMID: 25265644
15. This report presents the first case of an intragenic deletion within the NFIA gene that is still consistent with classic clinical phenotypes present in previously reported cases of chromosome 1p31.3 related deletion. PMID: 24462883
16. High nuclear factor IA expression is associated with glioblastomas. PMID: 24305710
17. These studies represent the first characterization of miR-223/NFIA axis function in glioma PMID: 23946414
18. These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder. PMID: 22925353
19. NFIA expression in white matter lesions of human newborns with neonatal HIE, as well active MS lesions in adults, revealed that it is similarly expressed in oligodendrocyte progenitors and not oligodendrocytes. PMID: 22807310
20. Role in the expression mechanism of hNaPi-IIb gene transcription. PMID: 15458926
21. nuclear factor I has a role in the intrinsic control of cerebellar granule neuron gene expression PMID: 15466411
22. Distribution of nuclear factor I binding sites correlate with Z-DNA forming regions in human chromosome 22. PMID: 15598822
23. Data show that human granulocytic differentiation is controlled by a regulatory circuitry involving miR-223 and two transcriptional factors, NFI-A and C/EBPalpha. PMID: 16325577
24. The NF1-A transcription factor plays an important role in the transcriptional activation of the TR2 orphan receptor gene expression via a promoter activating cis-element. PMID: 17010934
25. The mouse Nfia mutant phenotype and the common features among five human cases indicate that NFIA haploinsufficiency contributes to a novel human central nervous system malformation syndrome that can also include ureteral and renal defects. PMID: 17530927
26. NFI family of transcription factors plays a key role in the regulation of both the B-FABP and GFAP genes in malignant glioma cells. PMID: 19540848
27. in early hematopoiesis, the NFI-A expression level acts as a novel factor channeling HPCs into either the E or G lineage PMID: 19542302
28. Disruption of the Nfia gene in the mouse causes perinatal lethality, agenesis of the corpus callosum and hydrocephalus. PMID: 10518556
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相關疾病：

Brain malformations with or without urinary tract defects (BRMUTD)
亞細胞定位：

Nucleus.
蛋白家族：

CTF/NF-I family
數據庫鏈接：

HGNC: 7784

OMIM: 600727

KEGG: hsa:4774

STRING: 9606.ENSP00000360231

UniGene: Hs.740757

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