NEO1 Antibody, FITC conjugated

說明書

中文名稱：

NEO1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA852917LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NEO1 Polyclonal antibody
Uniprot No.：

Q92859
基因名：

NEO1
別名：

Immunoglobulin superfamily DCC subclass member 2 antibody; NEO1 antibody; NEO1_HUMAN antibody; Neogenin antibody; Ngn (gene name) antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Neogenin protein (414-682AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
基因功能參考文獻：
1. Overexpression of Neo1 significantly reduced the GC cell sensitivity to cisplatin and increased the cell viability, motility and adhesion ability, and while silencing of Neo1 showed contrary results. PMID: 30064133
2. Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling. PMID: 28038459
3. Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
4. these results suggested that GD3 recruits gamma-secretase to lipid/rafts, allowing efficient cleavage of neogenin. PMID: 27288875
5. The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans PMID: 26518331
6. Neogenin influences both cadherin dynamics and junctional tension. PMID: 27029596
7. Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways PMID: 25909166
8. The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer. PMID: 25998984
9. These results show how repulsive guidance molecule acts as the central hub that links BMP2 and NEO1 and physically connects these fundamental signaling pathways. PMID: 25938661
10. Neogenin expression is inversely associated with breast cancer grade. PMID: 25416629
11. high-expression of neogenin-1 promotes gastric cancer proliferation and motility PMID: 24930499
12. miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin. PMID: 24657544
13. these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog pathway in medulloblastoma PMID: 23775842
14. two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner. PMID: 23744777
15. neogenin forms a ternary complex with both MT2 and HJV at the plasma membrane. The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the cell occurs after a retrograde trafficking through the TGN/Golgi compartments. PMID: 22893705
16. pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells PMID: 22705235
17. the proposed role of neogenin as a tumor suppressor in gliomas PMID: 22666451
18. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
19. Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B. PMID: 19570425
20. Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer. PMID: 20971194
21. neogenin negatively regulates the functions of BMP and that this effect of neogenin is mediated by the activation of RhoA. PMID: 21149453
22. results show that different isoforms of hemojuvelin may play unique physiological roles through defined interactions with distinct signaling proteins such as BMP2 and neogenin, and demonstrate that some of these interactions are defective. PMID: 18287331
23. This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain. PMID: 20575069
24. neogenin and restin have roles in proproliferation/survival action on ovarian cancer cells PMID: 12833147
25. neogenin may play a role in mammary carcinogenesis as well as morphogenesis PMID: 16324219
26. HJV-induced BMP signaling and hepcidin expression are not altered by neogenin overexpression or by inhibition of endogenous neogenin expr PMID: 18326817
27. the neogenin intracellular domain regulates gene transcription via nuclear translocation PMID: 18391016
28. neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface PMID: 18445598
29. Results show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin. PMID: 18583991
30. Results support that hepatic neogenin possesses two functions, mediation of cellular HJV release, and stimulation of HJV-enhanced hepcidin expression. PMID: 19564337
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily, DCC family
組織特異性：

Widely expressed and also in cancer cell lines.
數據庫鏈接：

HGNC: 7754

OMIM: 601907

KEGG: hsa:4756

STRING: 9606.ENSP00000261908

UniGene: Hs.388613

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