NEGR1 Antibody

說明書

中文名稱：

NEGR1兔多克隆抗體
貨號：

CSB-PA003394
規格：

￥1090
圖片：
Western Blot analysis of COLO205 cells using NEGR1 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q7Z3B1
基因名：

NEGR1
別名：

NEGR1 antibody; IGLON4 antibody; UNQ2433/PRO4993 antibody; Neuronal growth regulator 1 antibody; IgLON family member 4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human NEGR1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.
基因功能參考文獻：
1. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children. PMID: 28428959
2. NEGR1, strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings. PMID: 28969442
3. Single nucleotide polymorphism in NEGR1 gene is associated with major depressive disorder. PMID: 27479909
4. Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes PMID: 27005443
5. NEGR1 interacts with NPC2 and increases its protein stability; it has a role in obesity PMID: 27940359
6. Genetic variants associated with BMI and WHR in adults influence growth patterns and general and abdominal fat development from early childhood onwards. PMID: 25640768
7. We observed novel selection signals in CDKAL1 and NEGR1, well-known diabetes and obesity susceptibility genes PMID: 25370040
8. NEGR1 could be an important locus influencing certain personality dimensions in BN patients. PMID: 25245582
9. First study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity. PMID: 25072390
10. Data indicate strong associations with severe obesity for single nucleotide polymorphism (SNP) rs9939609 within the FTO gene and SNP rs2815752 near the NEGR1 gene. PMID: 23950990
11. Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. PMID: 23229156
12. Our study supports earlier reports of SH2B1 to be of importance in insulin sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2. PMID: 22443470
13. Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005 PMID: 21750520
14. Gene-treatment interactions were observed for long-term (NEGR1 rs2815752, Pmetformin*SNP = 0.028; FTO rs9939609, Plifestyle*SNP = 0.044) weight loss. PMID: 22179955
15. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
16. Data suggest that in addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network. PMID: 21427694
17. The results of these studies provide supporting evidence for MYEOV and NEGR1 as gene targets of 11q13 gains and 1p31 deletions in a neuroblastoma subset. PMID: 21624008
18. Observational study of gene-disease association. (HuGE Navigator) PMID: 20712903
19. Observational study of gene-disease association. (HuGE Navigator) PMID: 20724581
20. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20725061
21. Observational study of gene-disease association. (HuGE Navigator) PMID: 20816152
22. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
23. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20571754
24. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
25. Observational study of gene-disease association. (HuGE Navigator) PMID: 20816195
26. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
27. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20386550
28. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20520848
29. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20215397
30. Observational study of gene-disease association. (HuGE Navigator) PMID: 19746409
31. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19812171
32. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851340
33. Observational study of gene-disease association. (HuGE Navigator) PMID: 19910938
34. Observational study of gene-disease association. (HuGE Navigator) PMID: 19692490
35. Observational study of gene-disease association. (HuGE Navigator) PMID: 19164386
36. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19079261
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Immunoglobulin superfamily, IgLON family
數據庫鏈接：

HGNC: 17302

OMIM: 613173

KEGG: hsa:257194

STRING: 9606.ENSP00000350364

UniGene: Hs.146542

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