NCF4 Antibody
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中文名稱：NCF4兔多克隆抗體
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貨號：CSB-PA015529GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CGD3 antibody; MGC3810 antibody; NCF 4 antibody; NCF antibody; NCF-4 antibody; Ncf4 antibody; NCF4_HUMAN antibody; Neutrophil cytosol factor 4 antibody; Neutrophil cytosolic factor 4 antibody; Neutrophil NADPH oxidase factor 4 antibody; p40-phox antibody; p40phox antibody; SH3 and PX domain-containing protein 4 antibody; SH3PXD4 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NCF4
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
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基因功能參考文獻：
- NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW} PMID: 26289093
- NCF4 may induce ex- pression of NADPH oxidase enzymes, such as p67phox, p47phox, p22phox and NOX2, which lead to increased ROS levels. PMID: 24378533
- Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. PMID: 23982929
- The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity. PMID: 23576480
- Constitutive and inducible intracellular production of reactive oxygen species (ROS) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS generation. PMID: 22984083
- Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults. PMID: 21472827
- Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease. PMID: 22158027
- cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis PMID: 21956105
- Results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane. PMID: 21518975
- no association between SNP rs4821544 and the presence of granulomas in Crohn's disease PMID: 21122541
- cytosolic localisation depends on direct interaction with F-actin PMID: 20637895
- All mutations and some polymorphisms identified in the NCF4 gene in the autosomal forms of chronic granulomatous disease are listed. Review. PMID: 20167518
- p40(phox) functions primarily to regulate Fc gamma receptor-induced NADPH oxidase activity rather than assembly, and stimulates superoxide production via a phosphatidylinositol-3-phosphate signal that increases after phagosome internalization. PMID: 18711001
- Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils PMID: 11903052
- Multiple PU.1 sites cooperate in the regulation of p40(phox) transcription during granulocytic differentiation of myeloid cells. PMID: 12036891
- p40phox and p47phox PX domains interact with PI-containing membranes PMID: 12556460
- A model is proposed in which phosphorylation of p40PHOX on threonine 154 leads to an inhibitory conformation that shifts the balance toward an inhibitory role and blocks NADPH oxidase activation. PMID: 15035643
- review of p40phox role in NADPH oxidase dynamics and possible non-NADPH oxidase processes in phagocytic and non-phagocytic cells PMID: 16102984
- This study identifies a role for p40(phox) and PI(3)P in coupling FcgammaR-mediated phagocytosis to activation of the NADPH oxidase. PMID: 16880255
- analysis of the dual regulatory mechanism through the PX domain of p40(phox): its interaction with the actin cytoskeleton may stabilize NADPH oxidase in resting cells, and binding of PtdIns (3)P potentiates superoxide production upon agonist stimulation PMID: 17698849
- In Swedish men with rheumatoid arthritis there were several single nucleotide polymorphisms identified in NCF4. PMID: 17897462
- This study has confirmed NCF4 and IRGM are risk factors for ileal Crohn's disease in New Zealand Caucasians. PMID: 18580884
- Class III PI3K Vps34 is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18-dependent activation oxidase activation in response to S aureus and E coli PMID: 18755982
- regulates activity of NADPH oxidase which generates superoxide production in neutrophils. (review) PMID: 18807499
- p40(phox) binding to PtdIns(3)P is essential for phagocytosis-induced oxidant production in human neutrophils and its absence can be associated with disease. PMID: 19692703
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相關疾病：Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3)
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亞細胞定位：Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein.
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組織特異性：Expression is restricted to hematopoietic cells.
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數據庫鏈接：
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