NBR1 Antibody

說明書

中文名稱：

NBR1兔多克隆抗體
貨號：

CSB-PA286085
規格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded Human Skeletal Muslce Tissue using NBR1 Rabbit pAb diluted at 1:500

Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using NBR1 Rabbit pAb diluted at 1:500
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q14596
基因名：

NBR1
別名：

1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Recombinant Protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:200
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
基因功能參考文獻：
1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672
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亞細胞定位：

Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
數據庫鏈接：

HGNC: 6746

OMIM: 166945

KEGG: hsa:4077

STRING: 9606.ENSP00000343479

UniGene: Hs.277721

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