NAPRT Antibody
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中文名稱：NAPRT兔多克隆抗體
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貨號：CSB-PA015451GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：NAPRT
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別名：FHA HIT interacting protein antibody; FHA-HIT-interacting protein antibody; FHIP antibody; NAPRT1 antibody; NAPRTase antibody; Nicotinate phosphoribosyltransferase antibody; Nicotinate phosphoribosyltransferase domain containing 1 antibody; Nicotinate phosphoribosyltransferase domain-containing protein 1 antibody; Nicotinic acid phosphoribosyltransferase antibody; PNCB_HUMAN antibody; PP3856 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NAPRT1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
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基因功能參考文獻：
- No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma PMID: 28860121
- Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases PMID: 28416276
- High NAPRTase expression is associated with neoplasms. PMID: 26675378
- Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor. PMID: 24097869
- Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner PMID: 22570471
- NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression PMID: 21492230
- NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD PMID: 17604275
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亞細胞定位：Cytoplasm, cytosol.
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蛋白家族：NAPRTase family
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數據庫鏈接：
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