Mgll Antibody, Biotin conjugated

^{Rare Species}

說明書

中文名稱：

Mgll兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA013787LD01RA
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Mgll Polyclonal antibody
Uniprot No.：

Q8R431
基因名：

Mgll
別名：

Mgll antibody; Mgl2 antibody; Monoglyceride lipase antibody; MGL antibody; EC 3.1.1.23 antibody; Monoacylglycerol lipase antibody; MAGL antibody
宿主：

Rabbit
反應種屬：

Rat
免疫原：

Recombinant Rat Monoglyceride lipase protein (1-303AA)
免疫原種屬：

Rattus norvegicus (Rat)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
基因功能參考文獻：
1. 4 weeks of post-weaning social isolation increased aggressive grooming of a novel same-sex conspecific in male and female rats. Treatment with the MAGL inhibitor MJN110 eliminated this increase in aggressive grooming in both males and females, without reducing non-aggressive social behavior. Activation of the medial prefrontal cortex was increased by social interaction but was blunted by MJN110 only in females. PMID: 29292159
2. MGL has an important role in insulin secretion PMID: 26867016
3. expression of MAGL is distributed in certain cell types and time-dependently expressed in skeletal muscles after trauma, suggesting that MAGL may be involved in inflammatory response, fibrogenesis and regeneration during skeletal muscle wound healing PMID: 25921063
4. MAGL inhibitor JZL184 is able to inhibit the inflammatory response and interfere with contused muscle healing. PMID: 25912803
5. results suggest that MAGL regulates phagocytosis, but not LPS-mediated cytokine induction in microglia PMID: 26166819
6. the current findings support the therapeutic potential of FAAH and monoacylglycerol lipase inhibitors as a novel pharmacotherapy for pain PMID: 25041240
7. Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo. PMID: 23319656
8. Pretreatment with MAGL inhibitor URB602 significantly reduces neonatal hypoxic-ischemic brain damage and improves functional outcome. PMID: 22821058
9. Maternal deprivation induced a significant decrease in MAGL immunoreactivity in the rat hippocampal CA3 and CA1 areas, more marked in males than in females. PMID: 20599824
10. hydrolysis by means of monoglyceride lipase is a primary mechanism for 2-arachidonoylglycerol inactivation in intact neurons PMID: 12136125
11. MGL is localized in the enteric nervous system where endocannabinoids regulate intestinal motility. MGL is highly expressed in the epithelium, where this enzyme may have digestive or other functions yet to be determined. PMID: 18948437
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亞細胞定位：

Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
蛋白家族：

AB hydrolase superfamily, Monoacylglycerol lipase family
組織特異性：

Ubiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain.
數據庫鏈接：

KEGG: rno:29254

STRING: 10116.ENSRNOP00000030271

UniGene: Rn.40396

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