MZB1 Antibody
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中文名稱：MZB1兔多克隆抗體
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貨號：CSB-PA893286
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規(guī)格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：MZB1
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別名：MZB1 antibody; Caspase 2 binding protein antibody; FLJ32987 antibody; HSPC190 antibody; Marginal zone B and B1 cell specific protein antibody; Marginal zone B- and B1-cell-specific protein antibody; MEDA 7 antibody; MEDA-7 antibody; Mesenteric estrogen dependent adipose 7 antibody; Mesenteric estrogen-dependent adipose 7 antibody; Mesenteric oestrogen dependent adipose gene 7 antibody; MGC29506 antibody; Mzb1 antibody; MZB1_HUMAN antibody; PACAP antibody; pERp1 antibody; Plasma cell-induced ER protein 1 antibody; Plasma cell-induced resident endoplasmic reticulum protein antibody; Plasma cell-induced resident ER protein antibody; Proapoptotic caspase adapter protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide from Human protein at AA range: 1-50
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：IHC,ELISA
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推薦稀釋比：
Application Recommended Dilution IHC IHC-p:1:50-300 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
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基因功能參考文獻：
- expression was positively correlated with a high accumulation of CD8(+) tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy PMID: 29180208
- Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection. PMID: 27459504
- High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature. PMID: 23189934
- miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID: 24014023
- results suggested that MGC29506 has the potential of functioning as a novel suppressor gene in gastric cancer PMID: 23434460
- methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis PMID: 22573353
- Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer. PMID: 22613335
- MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506] PMID: 12792799
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亞細胞定位：[Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
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蛋白家族：MZB1 family
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組織特異性：Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.
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數(shù)據(jù)庫鏈接：
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