MYT1 Antibody, Biotin conjugated
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中文名稱：MYT1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA015387LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MYT1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：C20orf36 antibody; KIAA0835 antibody; KIAA1050 antibody; MTF1 antibody; Myelin transcription factor 1 antibody; Myelin transcription factor I antibody; MYT1 antibody; MYT1_HUMAN antibody; MyTI antibody; PLPB1 antibody; Proteolipid protein-binding protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Myelin transcription factor 1 protein (317-451AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
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基因功能參考文獻：
- A novel missense variant affecting function, c.323C>T (p.(Ser108Leu)), was identified in MYT1, in a patient presenting with a severe form of OAVS. MYT1 overexpression downregulated all RA receptors genes in vitro. PMID: 28612832
- although depletion of MYT1 alone did not affect long-term cell growth, it potentiated with DNA damage to inhibit cell growth in clonogenic survival and tumor xenograft models PMID: 23146904
- present in brain in infancy and prenatally in infants with periventricular leukomalacia PMID: 12524179
- These results suggesta potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination. PMID: 17330875
- UVA-induced caspase-3 cleavage and DNA fragmentation were suppressed by the knockdown of human Myt1 in skin cancer cells. PMID: 19204086
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亞細胞定位：Nucleus.
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蛋白家族：MYT1 family
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組織特異性：Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
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數據庫鏈接：
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