MYO9B Antibody
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中文名稱：MYO9B兔多克隆抗體
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貨號：CSB-PA273051
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HeLa cells and Jurkat cells, using MYO9B antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MYO9B Polyclonal antibody
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Uniprot No.：
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基因名：MYO9B
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from N-terminal of Human MYO9B.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.
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基因功能參考文獻：
- Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease. PMID: 28627089
- data indicate that polymorphisms in MY09B are associated with the risk of inflammatory bowel disease PMID: 27556856
- Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP. PMID: 27363609
- meta-analysis indicates that MYO9B gene polymorphisms might be not associated with coeliac disease susceptibility in Caucasians. [meta-analysis] PMID: 27219348
- this meta-analysis shows that MYO9B genetic polymorphism is associated with Crohn's disease and ulcerative colitis PMID: 27435931
- newly defined SLIT/ROBO/Myo9b/RhoA signaling pathway that restricts lung cancer progression and metastasis. PMID: 26529257
- Our data suggest a link between MYO9B variants to an increased intestinal permeability in Crohn's disease patients. PMID: 25098938
- Results does not support the association of MYO9B with schizophrenia in Chinese population. PMID: 25710847
- MYO9B SNPs may influence the sub-phenotypic expression of Crohn's disease but did not find an association between these MYO9B polymorphisms and intestinal permeability in IBD. PMID: 24966617
- Variants in MYO9B may be involved in acute pancreatitis PMID: 24386489
- genetic variation MYO9B gene is associated with celiac disease as a protective or a risk factor PMID: 23368647
- The homozygous G/G group of theMyo9B polymorphism was associated with an increased risk for Barrett's esophagus and esophageal adenocarcinoms (EAC) development. Also the heterozygous A/G genotype was associated with an increased risk for EAC development. PMID: 22954106
- critical roles for Myo9b during epithelial wound healing and maintenance of tight junction integrity-key functions that may be altered in patients with Myo9b-linked inflammatory bowel disease. PMID: 22573889
- we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia found no evidence for association with these two loci. PMID: 21688385
- These data demonstrate an association of MYO9B with ileal CD. PMID: 21515326
- gene polymorphism is associated with type i diabetes in Dutch but not in Brotosh population PMID: 20303373
- Myosin-IXb is a single-headed and processive motor PMID: 11801597
- myosin IXb binds to BIG1, which regulates its Rho-GTPase activating protein activity PMID: 15644318
- Individuals homozygous with respect to the at-risk allele have a 2.3-times higher risk of celiac disease (P = 1.55 x 10(-5)). PMID: 16282976
- myosin IX uses a unique ATP hydrolysis mechanism PMID: 16338935
- Genotyping of the three SNPs which tagged the associated haplotype was performed in a Celiac disease family dataset in a Swedish/Norwegian cohort. PMID: 16720215
- tested the association between celiac disease and the three most associated single nucleotide polymorphisms by the transmission disequilibrium test in the Italian population PMID: 16943798
- Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. PMID: 17087940
- Results support a negligible influence of MYO9B polymorphisms on celiac disease predisposition. PMID: 17176439
- The MYO9B gene rs 2305764 polymorphism is not associated to coeliac disease in coeliac children from southern Italy. The allelic frequences of the polymorphism found in these patients and in the population control were not statistically different. PMID: 17267307
- study suggests that genetic variation in MYO9B is associated with celiac disease, systemic lupus erythematosus, and rheumatoid arthritis and that MYO9B is a general risk factor for autoimmunity PMID: 17584584
- Our data and the results of our meta-analysis question the role of MYO9B as a causative gene for celiac disease. PMID: 17667713
- study did not confirm the association of celiac disease with the CELIAC4 region polymorphisms described in other populations PMID: 17767555
- demonstrate significant association of allelic variants in MYO9B with schizophrenia. To our knowledge, this is the first molecular genetic evidence for a correlation between autoimmune diseases and the risk of developing schizophrenia PMID: 17948900
- MYO9B homozygosity might be involved in the prognosis of CD and the chance of developing RCD II and EATL. PMID: 17967566
- Myosin IXB variants were not associated with coeliac disease in this study; however, weak evidence of association with dermatitis herpetiformis was found. PMID: 18077767
- Minor alleles of rs962917, rs2279003, and rs2305764 polymorphisms were more frequent in diabetic patients than in controls and the haplotype carrying major alleles in rs962917*G/rs2279003*C/rs2305764*G, significantly reduced the risk of type 1 diabetes PMID: 18361936
- No association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations PMID: 19142207
- MYO9B variants may be involved in inflammatory bowel disease pathogenesis PMID: 19235913
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相關疾病：Celiac disease 4 (CELIAC4)
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亞細胞定位：Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
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組織特異性：Detected in peripheral blood leukocytes (at protein level). Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.
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