MYO1A Antibody
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中文名稱：MYO1A兔多克隆抗體
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貨號：CSB-PA015338GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MYO1A
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別名：BBM I antibody; BBM-I antibody; BBMI antibody; Brush border myosin I antibody; DFNA48 antibody; MIHC antibody; MYHL antibody; Myo1a antibody; MYO1A_HUMAN antibody; Myosin I heavy chain antibody; Myosin, heavy polypeptide like (100kD) antibody; Myosin-IA antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MYO1A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Involved in directing the movement of organelles along actin filaments.
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基因功能參考文獻：
- These data do not support a causal relationship of variants in MYO1A to sensorineural hearing loss. We suggest that the genotypic ascertainment method is useful to objectively evaluate gene-phenotype associations. PMID: 27759032
- This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
- One missense variant, p.R544W, was found in the MYO1A gene, and in silico analysis suggested that this variant has deleterious effects on protein function. PMID: 25080041
- Most of the altogether 10 MYO1A mutations are annotated in dbSNP, and population frequencies (dbSNP, 1000 Genomes, Exome Sequencing Project) above 0.1% contradict pathogenicity under a dominant model PMID: 24616153
- findings suggest that MYO1A has tumor suppressor activity in the normal gastric epithelium but not in the normal endometrium and inactivation of MYO1A either genetically or epigenetically may confer gastric epithelial cells a growth ad PMID: 23002058
- Myo1a targeting to microvilli is driven by membrane binding potential that is distributed throughout TH1 rather than localized to a single motif. PMID: 22367206
- results identify MYO1A as a unique tumor-suppressor gene in colorectal cancer and demonstrate that the loss of structural brush border proteins involved in cell polarity are important for tumor development PMID: 22307608
- MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells PMID: 11916846
- mapping of a novel autosomal dominant non-syndromic deafness locus, DFNA48, to chromosome 12q13-q14 in an Italian family PMID: 12596055
- Multiple mutations of MYO1A, a cochlear-expressed gene, were studied in sensorineural hearing loss. PMID: 12736868
- This movement is based on an active and directed process that is facilitated by an acto-NMI complex, establishing for the first time a functional role for a motor complex consisting of actin and a myosin in the nucleus. PMID: 16936815
- These data are the first to suggest that mechanical activity is essential for proper localization of Myo1a in microvilli. PMID: 17981900
- Sensing molecular tension is crucial for a wide array of cellular processes. Myosin I dramatically alters its motile properties in response to tension. PMID: 18599791
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
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數據庫鏈接：
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