MUC20 Antibody

說(shuō)明書(shū)

中文名稱：

MUC20兔多克隆抗體
貨號(hào)：

CSB-PA822693LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: MUC20 antibody at 5.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72, 69 kDa
Observed band size: 72 kDa

IHC image of CSB-PA822693LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA822693LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MUC20 Polyclonal antibody
Uniprot No.：

Q8N307
基因名：

MUC20
別名：

MUC 20 antibody; MUC-20 antibody; Muc20 antibody; MUC20_HUMAN antibody; Mucin 20 antibody; Mucin 20, cell surface associated antibody; Mucin-20 antibody; Transmembrane mucin MUC20S antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Mucin-20 protein (569-657AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，MUC20 Antibody (CSB-PA822693LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于MUC20 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA822693LB01HU	MUC20 Antibody, HRP conjugated	ELISA
FITC	CSB-PA822693LC01HU	MUC20 Antibody, FITC conjugated
Biotin	CSB-PA822693LD01HU	MUC20 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000
IF	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
基因功能參考文獻(xiàn)：
1. High MUC20 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma. PMID: 26673820
2. Results suggest that MUC20 enhances aggressive behaviors of EOC cells by activating integrin beta1 signaling and provide novel insights into the role of MUC20 in ovarian cancer metastasis. PMID: 26616226
3. MUC20 is a novel transmembrane mucin expressed by the human corneal and conjunctival epithelia, and suggest that differential expression of MUC20 during differentiation has a role in maintaining ocular surface homeostasis. PMID: 25168902
4. MUC20 is expressed in recurrent colorectal neoplasms and may have a role in poor outcome PMID: 23787019
5. Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway. PMID: 15314156
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亞細(xì)胞定位：

Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.
組織特異性：

Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with th
數(shù)據(jù)庫(kù)鏈接：

HGNC: 23282

OMIM: 610360

KEGG: hsa:200958

STRING: 9606.ENSP00000396774

UniGene: Hs.308992

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