MTMR14 Antibody
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中文名稱：MTMR14兔多克隆抗體
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貨號：CSB-PA847682ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA847682ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA847682ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MTMR14 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：C3orf29 antibody; Egg derived tyrosine phosphatase homolog antibody; FLJ11546 antibody; FLJ22405 antibody; FLJ46453 antibody; FLJ90311 antibody; HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody; hEDTP antibody; hJumpy antibody; jumpy antibody; MTMR 14 antibody; MTMR14 antibody; MTMRE_HUMAN antibody; Myotubularin related protein 14 antibody; Myotubularin-related protein 14 antibody; NS5ATP4ABP1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Myotubularin-related protein 14 protein (1-280AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
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基因功能參考文獻：
- This study provides the first in vivo evidence for a role of myotubularins, and in particular MTMR14, in the regulation of autophagy. PMID: 20595810
- The authors uncovered a key negative regulatory role in autophagy of a phosphatidylinositol 3-phosphate (PI3P) phosphatase Jumpy (MTMR14). PMID: 19590496
- Study identified a novel phosphoinositide phosphatase, JUMPY in sporadic cases of centronuclear myopathy; two missense variants that affect the enzymatic function were found PMID: 17008356
- C3orf29 encodes hJUMPY, a phosphoinositide 3-phosphate phosphatase that acts on PtdIns3P and PtdIns(3,5)P2. A missense mutation disrupts the catalytic activity in a patient with centronuclear myopathy. PMID: 17008356
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相關疾病：Myopathy, centronuclear, 1 (CNM1)
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亞細胞定位：Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
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蛋白家族：Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
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組織特異性：Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
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數據庫鏈接：
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