MTERF1 Antibody, HRP conjugated

說明書

中文名稱：

MTERF1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA811872LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MTERF1 Polyclonal antibody
Uniprot No.：

Q99551
基因名：

MTERF1
別名：

mitochondrial antibody; Mitochondrial transcription termination factor 1 antibody; mTERF antibody; MTERF_HUMAN antibody; Transcription termination factor antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcription termination factor 1, mitochondrial protein (63-232AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.
基因功能參考文獻：
1. MTERF1 has the ability to accommodate alternate active conformations. PMID: 26523681
2. It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE. PMID: 27112570
3. Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. PMID: 21326908
4. Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer. PMID: 21447778
5. data suggested that hMTERF4 is an essential factor for cell proliferation, which is probably modulated by mitochondrial transcription to promote cell proliferation PMID: 21450691
6. Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms. PMID: 20846394
7. Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. PMID: 20543826
8. The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides. PMID: 20550934
9. mTERF mRNA levels were higher in elite athletes compared with moderately active subjects PMID: 19681768
10. mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex PMID: 14744862
11. monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro PMID: 15899902
12. analysis of DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF PMID: 16336784
13. Results indicate a role for mTERF in mtDNA replication, in addition to its role in transcription. PMID: 17884915
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亞細胞定位：

Mitochondrion.
蛋白家族：

MTERF family
數據庫鏈接：

HGNC: 21463

OMIM: 602318

KEGG: hsa:7978

STRING: 9606.ENSP00000248643

UniGene: Hs.532216

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