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中文名稱：MTA3兔多克隆抗體
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貨號：CSB-PA015127GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MTA3
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別名：1110002J22Rik antibody; fj99h01 antibody; KIAA1266 antibody; Metastasis associated 1 family, member 3 antibody; Metastasis associated 3 antibody; Metastasis associated family, member 3 antibody; Metastasis associated gene 3 antibody; Metastasis associated gene family, member 3 antibody; Metastasis associated protein MTA3 antibody; Metastasis-associated protein MTA3 antibody; MGC56396 antibody; MGC77410 antibody; mKIAA1266 antibody; mta1 antibody; Mta3 antibody; MTA3 metastasis associated 1 family, member 3 antibody; Mta3 metastasis associated 3 antibody; MTA3_HUMAN antibody; wu:fj99h01 antibody; zgc:56396 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MTA3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- iTRAQ-based comparative proteomic analysis of cells infected with Eimeria tenella sporozoites Zhao Z, et al,Parasite,2019
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靶點詳情
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功能：Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
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基因功能參考文獻：
- Results show that metastasis associated 1 family member 3 (MTA3) level was decreased in colorectal cancer and significantly correlated with tumor cell invasion and metastasis, and that MTA3 might serve as a potential marker of tumor recurrence and prognosis of colorectal cancer. PMID: 28418887
- MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment. PMID: 27992674
- As a master regulator, MTA3 governs the target selection for nucleosome remodeling and histone deacetylation and functions as a transcriptional repressor. MTA3 dysregulation is associated with tumor progression, invasion, and metastasis in various cancers. MTA is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition. PMID: 28279208
- MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression PMID: 23840517
- Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer PMID: 28351306
- Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers. PMID: 27033852
- role in terminal trophoblast differentiation PMID: 26198267
- MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. PMID: 26483332
- This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors. PMID: 25319202
- MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival. PMID: 24107548
- Using western blotting and luciferase assays, MTA3 was identified as a target of miR-495 PMID: 24293376
- MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma. PMID: 23671646
- Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia. PMID: 23510993
- MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas PMID: 20865667
- The absence of MTA3 leads to aberrant expression of Snail, a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin, causing changes in epithelial architecture and invasive growth. PMID: 12705869
- MTA3 does not repress transcription to a significant level and appears to have a diffused pattern of subcellular localization, suggesting a biological role distinct from that of the other two MTA proteins. PMID: 12920132
- estrogen receptor-alpha regulates metastatic tumor antigen 3 pathway PMID: 15169784
- Molecular dissection of the MTA3 promoter using transient transfection assays identified a composite element required for high-level transcription consisting of an SP1 site in close proximity to a consensus estrogen response element half-site. PMID: 15358836
- a cell type-specific subunit of the corepressor complex Mi-2/NuRD,a cofactor for BCL-6-dependent B cell fate determination. PMID: 15454082
- These findings identify MTA3 as an upstream physiologic repressor of Wnt4 in mammary epithelial cells. PMID: 17050676
- the high expression level of MTA proteins in human chorionic cells might facilitate trophoblast cell migration and neoangiogenesis PMID: 19363681
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亞細胞定位：Nucleus.
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組織特異性：Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
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數據庫鏈接：
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