MT1G Antibody

文獻引用 (4) 說明書

中文名稱：

MT1G兔多克隆抗體
貨號：

CSB-PA17384A0Rb
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA17384A0Rb at dilution of 1: 100
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品描述：

CUSABIO produced the MT1G polyclonal antibody (CSB-PA17384A0Rb) by immunizing rabbits with the synthetic peptide corresponding to the amino acids 1-59 of the recombinant human MT1G protein. The anti-MT1G antibody was purified from rabbit antiserum by protein G affinity chromatography. Its purity reaches up to 95%. It occurs as an unconjugated IgG.

This MT1G polyclonal antibody only reacts with human MT1G, which suppresses growth, migration, and invasion but induces cell cycle arrest and apoptosis in thyroid cancer cells. This MT1G antibody is suitable for the detection of MT1G protein in ELISA and IHC applications.
產品名稱：

Rabbit anti-Homo sapiens (Human) MT1G Polyclonal antibody
Uniprot No.：

P13640
基因名：

MT1G
別名：

Metallothionein-1G antibody; Metallothionein-1K antibody; Metallothionein-IG antibody; MT-1G antibody; MT-1K antibody; MT-IG antibody; MT1G antibody; MT1G_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Metallothionein-1G protein (1-59AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MT1G Antibody (CSB-PA17384A0Rb)，的標記方式是Non-conjugated。對于MT1G Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA17384B0Rb	MT1G Antibody, HRP conjugated	ELISA
FITC	CSB-PA17384C0Rb	MT1G Antibody, FITC conjugated
Biotin	CSB-PA17384D0Rb	MT1G Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Ferroptosis‐Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease P Liu, Q Liu, Y Tian, P Cai, J Bai,Immunity, Inflammation and Disease,2025
MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression S Wang,British journal of cancer,2024
Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer Z Zhou,Journal of experimental & clinical cancer research,2024
MT1G, an emerging ferroptosis‐related gene: A novel prognostic biomarker and indicator of immunotherapy sensitivity in prostate cancer B Cheng,Environmental toxicology,2023

產品評價

靶點詳情

功能：

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
基因功能參考文獻：
1. These findings indicate that MT1 constitute a biomarker adapted for exploring the impact of sorafenib on the redox metabolism of cancer cells. PMID: 27184800
2. A new tumor-suppressor activity of MT1G in colorectal cancer cells.MT1G role in cell differentiation. PMID: 28393194
3. PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation PMID: 25072246
4. MT1G was down-regulated in renal cell carcinogenesis. PMID: 24662736
5. MT1M and MT1G promoter methylation may be used as serum biomarkers for noninvasive detection of hepatocellular carcinoma. PMID: 24782625
6. Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy. PMID: 24634414
7. Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. PMID: 24098937
8. GPR56, MT1G, and RASSF1 might be the potential methylation markers associated with acquired multidrug resistance of lung adenocarcinoma. PMID: 23902976
9. Results describe MT1G promoter hypermethylation in hepatoblastoma and demonstrate that aberrant methylation is a frequent event in this malignancy. PMID: 20032811
10. Loss of metallothionein 1G function due to hypermethylation of its promoter leads to athogenesis of papillary thyroid carcinoma PMID: 12640681
11. Induction of the hMT1G promoter by VEGF and heavy metals occurs through the utilization of different transcription factors. PMID: 15735762
12. Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity. PMID: 15747776
13. MT1G is hypermethylated in renal cell carcinoma. PMID: 18639284
14. Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively and may have utility for early detection of esophageal squamous dysplasia and early ESCC. PMID: 19137073
15. Promoter methylation and differential gene expression of five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, respectively. PMID: 19491193
16. p16INK4A, DAPK1, PTEN and MT1G genes were not frequently methylated in the stage I non-small cell lung cancer in China. PMID: 19506903
17. MT1G acts as a tumor suppressor gene in hepatocellular carcinoma PMID: 19639168
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蛋白家族：

Metallothionein superfamily, Type 1 family
數據庫鏈接：

HGNC: 7399

OMIM: 156353

KEGG: hsa:4495

STRING: 9606.ENSP00000391397

UniGene: Hs.433391

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