MSH5 Antibody

說明書

中文名稱：

MSH5兔多克隆抗體
貨號：

CSB-PA066219
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA066219(MSH5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA066219(MSH5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse bladder tissue, Primary antibody: CSB-PA066219(MSH5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O43196
基因名：

MSH5
別名：

DKFZp434C1615 antibody; G7 antibody; hMSH5 antibody; MGC2939 antibody; MSH 5 antibody; MSH5 antibody; MSH5_HUMAN antibody; mutS (E. coli) homolog 5 antibody; mutS homolog 5 antibody; mutS homolog 5 (E. coli) antibody; MutS protein homolog 5 antibody; MutSH5 antibody; NG23 antibody; OTTHUMP00000029187 antibody; OTTHUMP00000029188 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human MSH5
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.
基因功能參考文獻：
1. From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence PMID: 28175301
2. our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress. PMID: 26055704
3. the roles of hMSH5 variants in the processes of DNA damage response and repair PMID: 24023853
4. Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. PMID: 22917773
5. Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin. PMID: 22401567
6. The presence of the MSH5 85F allele marks the subgroup of DRB1*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors. PMID: 20542071
7. hMSH5 possesses a CRM1-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting. PMID: 20185565
8. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
9. A review of the properties and functional roles of MSH5. PMID: 17127347
10. These findings suggest that Msh4/5 heterodimers contribute to class switch recombination. PMID: 17409188
11. Data show that MSH5 mutations may be one explanation for premature ovarian failure. PMID: 18166824
12. Biochemical identification of the proteins with which it interacted showed that SMCY formed a distinct complex with MSH5, a critical meiosis-regulatory protein in the human testicular germ cell line, NEC8. PMID: 18459961
13. this study implicates a role for hMSH5 in DNA damage response involving c-Abl and p73, and suggests that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments. PMID: 19442657
14. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918
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相關疾病：

Premature ovarian failure 13 (POF13)
蛋白家族：

DNA mismatch repair MutS family
組織特異性：

Widely expressed, with high levels in testis and ovary, including granulosa cells. Also expressed in fetal ovary and adrenal gland.
數據庫鏈接：

HGNC: 7328

OMIM: 603382

KEGG: hsa:4439

STRING: 9606.ENSP00000364855

UniGene: Hs.647011

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