MSH4 Antibody

中文名稱：

MSH4兔多克隆抗體
貨號：

CSB-PA015030LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse lung tissue, Mouse kidney tissue, Human placenta tissue
All lanes: MSH4 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 105 kDa
Observed band size: 105 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015030LA01HU at dilution of 1:100

Immunofluorescence staining of Hela cell with CSB-PA015030LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MSH4 Polyclonal antibody
Uniprot No.：

O15457
基因名：

MSH4
別名：

hMSH4 antibody; MSH 4 antibody; MSH4 antibody; MSH4_HUMAN antibody; MutS homolog 4 (E. Coli) antibody; MutS homolog 4 antibody; MutS protein homolog 4 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human MutS protein homolog 4 protein (501-800AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MSH4 Antibody (CSB-PA015030LA01HU)，的標記方式是Non-conjugated。對于MSH4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA015030LB01HU	MSH4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA015030LC01HU	MSH4 Antibody, FITC conjugated
Biotin	CSB-PA015030LD01HU	MSH4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
基因功能參考文獻：
1. Study describes the first MSH4 mutation associated with POI and increases the number of meiotic/DNA repair genes formally implicated as being responsible for this condition. PMID: 28541421
2. inactivation of MSH4 in germ cells may have played a role in the acquisition of additional TP53 and LATS1 germline mutations in a Li-Fraumeni family PMID: 25041856
3. hMSH4 interacts with HDAC3. PMID: 24145748
4. Our current study has revealed a role for hMSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair. PMID: 23725059
5. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages PMID: 21126912
6. The different properties associated with these two hMSH5 variants underscore the potential functional diversity of the human hMSH5 gene. PMID: 15907804
7. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination. PMID: 16122992
8. A review of the properties and functional roles of MSH4. PMID: 17127347
9. Dimerization of MSH4 and MSH5 facilitates their nuclear localization suggesting that dimerization may regulate the intracellular trafficking of these proteins. PMID: 17869244
10. Data have identified the interaction region between the individual subunits of hMSH4-hMSH5 that are likely involved in clamp formation and show that each subunit of the heterodimer binds ATP. PMID: 17977839
11. Data show that there is no association between MSH4 gene mutation and premature ovarian failure. PMID: 18166824
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亞細胞定位：

Chromosome.
蛋白家族：

DNA mismatch repair MutS family
組織特異性：

Testis and ovary specific.
數據庫鏈接：

HGNC: 7327

OMIM: 602105

KEGG: hsa:4438

STRING: 9606.ENSP00000263187

UniGene: Hs.216639

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