MPS1 Antibody

^{Rare Species}

說明書

中文名稱：

MPS1 Antibody
貨號：

CSB-PA346524XA01SVG
規格：

￥880
圖片：
Western Blot
Positive WB detected in: recombinant protein
All lanes: MPS1 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MPS1 Polyclonal antibody
Uniprot No.：

P54199
基因名：

MPS1
別名：

Serine/threonine-protein kinase MPS1 (EC 2.7.12.2) (Monopolar spindle protein 1) (Regulatory cell proliferation kinase 1) MPS1 RPK1 YDL028C D2785
宿主：

Rabbit
反應種屬：

Saccharomyces cerevisiae (Baker's yeast)
免疫原：

Recombinant Saccharomyces cerevisiae (Baker's yeast) MPS1 protein (40-289aa)
免疫原種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues. Phosphorylates the SPC29 and SPC110 spindle pole body components.
基因功能參考文獻：
1. An important role for Mps1 phosphorylation in the spindle assembly checkpoint activation, beyond the direct recruitment of Mad1 and Mad2. PMID: 27280788
2. CCT271850 is a potent, selective and orally bioavailable MPS1 kinase inhibitor. On the basis of in vivo pharmacodynamic vs efficacy relationships, we predict that more than 80% inhibition of MPS1 activity for at least 24 h is required to achieve tumour stasis or regression by CCT271850. PMID: 28334731
3. These findings highlight MPS1 as a rational therapeutic target for medulloblastoma PMID: 27633003
4. Disrupting Mps1 before mitotic entry reduces chromosomal passenger complex (CPC) localization to the centromere. Mps1 plays a minimal role in maintaining CPC localization once cells are in mitosis. PMID: 25854549
5. Mps1 kinase controls Cnn1 localization and activity at kinetochores through the cell cycle. PMID: 25716979
6. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. PMID: 23371552
7. found that Sgo1 overexpression rescues defects caused by metaphase inactivation of Mps1 and that Mps1 is required for Sgo1 localization to the kinetochore PMID: 21389114
8. Mps1 plays an important role in kinetochore attachment during mitotic spindle assembly and function. PMID: 15668173
9. it was demonstrated that mutual inhibition between the anaphase-promoting complex (APC) and Mps1, an essential component of the checkpoint, leads to sustained inactivation of the spindle checkpoint PMID: 16825537
10. Phosphorylation of Dam1 residues S218 and S221 by Mps1 is required for efficient coupling of kinetochores to microtubule plus ends. PMID: 16890524
11. Mps1 promotes re-orientation of kinetochore-spindle pole connections and eliminates those that do not generate tension between sister kinetochores. PMID: 18060784
12. Results suggest that a putative Mps1-dependent phosphorylation of Ndc80 is important for spindle assembly checkpoint activation at kinetochores. PMID: 19300438
顯示更多

收起更多
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
數據庫鏈接：

KEGG: sce:YDL028C

STRING: 4932.YDL028C

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human