MOAP1 Antibody
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中文名稱：MOAP1兔多克隆抗體
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貨號(hào)：CSB-PA014693ESR2HU
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規(guī)格：￥440
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MOAP1 Polyclonal antibody
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Uniprot No.：
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基因名：MOAP1
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別名：MAP 1 antibody; MAP-1 antibody; MAP1 antibody; MOAP1 antibody; MOAP1_HUMAN antibody; Modulator of apoptosis 1 antibody; Modulator of Apoptosis antibody; Paraneoplastic antigen like 4 antibody; Paraneoplastic antigen Ma4 antibody; paraneoplastic Ma antigen family member 4 antibody; PNMA4 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Modulator of apoptosis 1 protein (1-351AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
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基因功能參考文獻(xiàn)：
- RACK1 associates with MOAP-1 via electrostatic associations similar to those observed between MOAP-1/RASSF1A and MOAP-1/TNF-R1. These events illustrate the complex nature of MOAP-1 regulation and characterizes the important role of the scaffolding protein, RACK1, in influencing MOAP-1 biology. PMID: 29470995
- These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria. PMID: 27320914
- UBR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cisplatin resistance in ovarian cancer. PMID: 27721409
- Paraneoplastic Ma antigen-like 1 is suggested as a novel potential clinically useful prognostic biomarker for patients with pancreatic ductal adenocarcinoma. PMID: 25251443
- PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction PMID: 27003254
- MOAP-1 is a tumor suppressor protein linked to the RASSF1A protein PMID: 26269600
- miR-25 promotes cell proliferation and inhibits apoptosis in non-small cell lung cancer cells by negatively regulating MOAP1 expression. PMID: 25998847
- PB1-F2 protein of influenza A virus interacts with human MOAP-1 protein. PMID: 23236846
- Enforced miR-1228 expression can reduce MOAP1 expression and delay the progression of stress-induced cell apoptosis. PMID: 22434376
- RASSF1A and MAP-1 are important components between death receptors and the apoptotic machenery. PMID: 15949439
- RASSF1A is a tumor suppressor that activates Bax via MOAP-1 PMID: 16344548
- Inhibition of ubiquitin-mediated degradation of MOAP1 by apoptotic stimuli promotes BAX function in mitochondria. PMID: 17535899
- The association of RASSF1A and MOAP-1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation. PMID: 18474619
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蛋白家族：PNMA family
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組織特異性：Widely expressed, with high levels in heart and brain.
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數(shù)據(jù)庫(kù)鏈接：
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