MNX1 Antibody

中文名稱：

MNX1兔多克隆抗體
貨號：

CSB-PA014692LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: HEK293 whole cell lysate
All lanes: MNX1 antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 21 kDa
Observed band size: 50 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MNX1 Polyclonal antibody
Uniprot No.：

P50219
基因名：

MNX1
別名：

HB 9 antibody; HB9 antibody; HLXB 9 antibody; HLXB9 antibody; Homeo box HB9 antibody; Homeobox HB9 antibody; Homeobox protein HB9 antibody; HOXHB9 antibody; MNX1 antibody; MNX1_HUMAN antibody; Motor neuron and pancreas homeobox 1 antibody; Motor neuron and pancreas homeobox protein 1 antibody; Sacral agenesis autosomal dominant (Currarino triad) antibody; SCRA 1 antibody; SCRA1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Motor neuron and pancreas homeobox protein 1 protein (50-99AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MNX1 Antibody (CSB-PA014692LA01HU)，的標記方式是Non-conjugated。對于MNX1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA014692LB01HU	MNX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA014692LC01HU	MNX1 Antibody, FITC conjugated
Biotin	CSB-PA014692LD01HU	MNX1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative transcription factor involved in pancreas development and function.
基因功能參考文獻：
1. MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM. PMID: 30066929
2. Pathogenic variants in MNX1 were detected in 28% of all CS cases and 25% of sporadic cases. The clinical phenotype was variable in patients with and without pathogenic variants; no significant genotype-phenotype correlation was observed. PMID: 29401559
3. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting. PMID: 28611045
4. MNX1 as a novel targetable oncogene increased in African-American (AA) prostate cancer that is associated with aggressive disease. PMID: 27578002
5. Findings demonstrated for the first time that lncRNA MNX1-AS1 functions as an oncogene in ovarian cancer. PMID: 28414551
6. The results illustrated miR-200a and miR-141 could inhibit the expression of Hlxb9 by binding to its mRNA 3'UTR. Furthermore, the expression of miR-200a and miR-141 was almost reciprocal to that of Hlxb9. Overexpression of miR-200a and miR-141 downregulated the expression of pancreatic progenitor cell markers Hlxb9 PMID: 26801823
7. The nuclear positioning of the HLXB9 gene was monitored at different stages. PMID: 25136833
8. study reports the results of MNX1 mutational screening in a series of 28 cases suspected having Currarino Syndrome and characterization of 10 novel mutations PMID: 24095820
9. NKX2-2 and MNX1 are etiological genes for neonatal diabetes. PMID: 24411943
10. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas) PMID: 24425879
11. study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375[12]) is a normal allelic variant PMID: 23370340
12. HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells. PMID: 23048027
13. a new HLXB9 gene mutation identified in a Chinese family with members suffering from Currarino syndrome PMID: 21960426
14. two novel mutations in the MNX1 gene in cases with Currarino syndrome PMID: 22820079
15. 2 previously described mutations, 1 de novo nonsense mutation (p.Gln212X) & 1 maternally inherited frameshift mutation (p.Pro18ProfsX38)were found among 14 Currarino syndrome patients with presacral tumors. PMID: 21763840
16. Hypermethylation of HLXB9 results in loss of expression and is associated with acute lymphoblastic leukemia. PMID: 21069786
17. HLXB9 is overexpressed in patients with infantile acute myeloid leukemia. PMID: 19446746
18. Incomeplete Curarino syndrome with more advantageous prognosis with autosomal domiant pattern homebox gene HLXBV9 mutation. PMID: 20146075
19. study reports on the MNX1 mutations in a family segregating Currarino syndrome (CS) & 3 sporadic CS patients & on clinical characteristics of the affected individuals PMID: 19853743
20. mutation in the HLXB9 transcription factor causes an autosomal dominant form of sacral agenesis PMID: 11940082
21. The chromosomal rearrangements of the HLXB9 protein locus at 7q36 were not detected in Hodgkin lymphoma cells unlike acute myeloid leukemia subsets expressing HLXB9. PMID: 15772702
22. High incidence of t(7;12)(q36;p13) in infant myeloid leukemia is associated with ectopic expression of HLXB9. PMID: 16646086
23. This study confirms that familial Currarino syndrome (CS) patients in Korea have the same genetic background as other ethnicities and reaffirms the phenotype variability among CS patients with the same mutation. PMID: 17612791
24. report 23 novel mutations in 26 patients among a series of 50 index cases with Currarino syndrome PMID: 18449898
25. MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia. PMID: 18940475
26. Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias PMID: 19212340
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相關疾病：

Currarino syndrome (CURRAS)
亞細胞定位：

Nucleus.
組織特異性：

Expressed in lymphoid and pancreatic tissues.
數據庫鏈接：

HGNC: 4979

OMIM: 142994

KEGG: hsa:3110

STRING: 9606.ENSP00000252971

UniGene: Hs.37035

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