MLXIP Antibody
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中文名稱：MLXIP兔多克隆抗體
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貨號：CSB-PA014644GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MLXIP
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別名：MLXIP antibody; BHLHE36 antibody; KIAA0867 antibody; MIR antibody; MONDOA antibody; MLX-interacting protein antibody; Class E basic helix-loop-helix protein 36 antibody; bHLHe36 antibody; Transcriptional activator MondoA antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MLXIP
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
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基因功能參考文獻：
- Data (including data from studies in knockout mice) suggest that MONDOA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (ARRDC4) and thioredoxin interacting protein (TXNIP). PMID: 29282201
- MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling PMID: 27500491
- Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism. PMID: 26910886
- These results suggest that C771G polymorphism of MLXIPL gene is associated with coronary stenosis and its severity. PMID: 25179879
- Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis PMID: 25640402
- An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia. PMID: 22748921
- Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes. PMID: 20385767
- Data show that for both MondoA and Mlx, the C-terminal domain CRM-1 has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm. PMID: 12446771
- Endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle. PMID: 16782875
- Data suggest that glutamine-dependent mitochondrial anapleurosis dictates glucose uptake and aerobic glycolysis by blocking MondoA:Mlx-dependent transcriptional activation of TXNIP. PMID: 19706488
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亞細胞定位：Cytoplasm. Nucleus. Mitochondrion outer membrane.
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組織特異性：Widely expressed in adult tissues. Most abundant in skeletal muscle.
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數據庫鏈接：
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