MLLT11 Antibody, FITC conjugated

說明書

中文名稱：

MLLT11兔多克隆抗體, FITC偶聯(lián)
貨號(hào)：

CSB-PA618752LC01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MLLT11 Polyclonal antibody
Uniprot No.：

Q13015
基因名：

MLLT11
別名：

AF1Q antibody; AF1Q_HUMAN antibody; ALL1 fused gene from chromosome 1q antibody; MLLT 11 antibody; MLLT11 antibody; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila) translocated to 11 antibody; Protein AF1q antibody; RP11 316M1.10 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Protein AF1q protein (1-90AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate.
基因功能參考文獻(xiàn)：
1. AF1q was up-regulated in human colorectal cancer tissues, and that this up-regulation was associated with tumor metastasis. AF1q contributes to CRC tumorigenesis through the activation of the AKT signaling pathway. PMID: 28475127
2. Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation. PMID: 27259262
3. AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression. PMID: 28423573
4. These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway. PMID: 28188793
5. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. PMID: 26079538
6. Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter. PMID: 26341630
7. AF1Q had a KFERQ-like motif. PMID: 24880125
8. AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown PMID: 22761939
9. Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors. PMID: 21715312
10. AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. PMID: 20596645
11. The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells. PMID: 15530661
12. overexpression of AF1Q leads to more progression in human breast cancer PMID: 17929166
13. The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance. PMID: 18852119
14. high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia PMID: 19396856
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相關(guān)疾病：

A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
亞細(xì)胞定位：

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

MLLT11 family
組織特異性：

Expressed in myoepithelial cells of normal breast tissue (at protein level). Highly expressed in thymus. Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen.
數(shù)據(jù)庫鏈接：

HGNC: 16997

OMIM: 604684

KEGG: hsa:10962

STRING: 9606.ENSP00000357917

UniGene: Hs.75823

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