MKRN1 Antibody

中文名稱：

MKRN1兔多克隆抗體
貨號：

CSB-PA883390LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA883390LA01HU diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MKRN1 Polyclonal antibody
Uniprot No.：

Q9UHC7
基因名：

MKRN1
別名：

E3 ubiquitin-protein ligase makorin-1 antibody; FLJ21334 antibody; HGNC:7112 antibody; Makorin antibody; Makorin ring finger protein 1 antibody; MKRN 1 antibody; mkrn1 antibody; MKRN1_HUMAN antibody; OTTHUMP00000212117 antibody; OTTHUMP00000212118 antibody; OTTHUMP00000212121 antibody; OTTHUMP00000212124 antibody; Ring finger protein 1 antibody; RING finger protein 61 antibody; RNF61 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase makorin-1 protein (109-209AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MKRN1 Antibody (CSB-PA883390LA01HU)，的標記方式是Non-conjugated。對于MKRN1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA883390LB01HU	MKRN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA883390LC01HU	MKRN1 Antibody, FITC conjugated
Biotin	CSB-PA883390LD01HU	MKRN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
基因功能參考文獻：
1. HAdV-C5 histone-like core protein pVII binds to and promotes self-ubiquitination of a cellular E3 ubiquitin ligase named MKRN1. This mutual interaction between the pVII and MKRN1 proteins may prime MKRN1 for proteasomal degradation, because the MKRN1 protein is efficiently degraded during the late phase of HAdV-C5 infection. PMID: 29142133
2. In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening. PMID: 26817873
3. EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. PMID: 26183061
4. Results verified MKRN1 as an ubiquitin E3 ligase of p14ARF, it potentially regulates cellular aging and tumorigenesis in gastric cancer. PMID: 23104211
5. MKRN1 could induce WNV capsid protein ubiquitination and degradation in a proteasome-dependent manner PMID: 19846531
6. MKRN1 may represent a nuclear protein with multiple nuclear functions, including regulating RNA polymerase II-catalyzed transcription. PMID: 16785614
7. Data indicate that MKRN1 is a novel modulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. PMID: 19536131
8. Makorin 1 is a novel SEREX antigen of esophageal squamous cell carcinoma PMID: 19604354
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組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 7112

OMIM: 607754

KEGG: hsa:23608

STRING: 9606.ENSP00000255977

UniGene: Hs.744883

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