MKL2 Antibody

中文名稱：

MKL2兔多克隆抗體
貨號(hào)：

CSB-PA891962LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, NIH/3T3 whole cell lysate
All lanes: MKL2 antibody at 4.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 119, 43, 52, 115, 120 kDa
Observed band size: 119 kDa

IHC image of CSB-PA891962LA01HU diluted at 1:500 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MKL2 Polyclonal antibody
Uniprot No.：

Q9ULH7
基因名：

MKL2
別名：

FLJ31823 antibody; Megakaryoblastic leukemia 2 antibody; megakaryoblastic leukemia 2 protein antibody; MKL/myocardin-like 2 antibody; MKL/myocardin-like protein 2 antibody; Mkl2 antibody; MKL2_HUMAN antibody; MRTF-B antibody; Myocardin-related transcription factor B antibody; NPD001 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human MKL/myocardin-like protein 2 protein (164-313AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，MKL2 Antibody (CSB-PA891962LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于MKL2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA891962LB01HU	MKL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA891962LC01HU	MKL2 Antibody, FITC conjugated
Biotin	CSB-PA891962LD01HU	MKL2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.
基因功能參考文獻(xiàn)：
1. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation. PMID: 29335431
2. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer. PMID: 26498848
3. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development. PMID: 23692340
4. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. PMID: 24968937
5. MKL1/2 depletion resulted in Ras activation, elevated p16 expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1-deficient hepatocellular carcinoma cells. PMID: 23853104
6. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas. PMID: 23672313
7. study provides evidence that MKL1/2 mediates cancerous transformation in DLC1-deficient hepatocellular and mammary carcinoma cells PMID: 22139079
8. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. PMID: 20607705
9. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro. PMID: 14565952
10. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases. PMID: 17947237
11. Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[ PMID: 18056415
12. RNA interference was used to investigate the contribution of the MRTF-SRF pathway to cytoskeletal dynamics in MDA-MB-231 breast carcinoma and B16F2 melanoma cells, in which basal MRTF-SRF activity is Rho-dependent. PMID: 19198601
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相關(guān)疾病：

A chromosomal aberration involving C11orf95 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with C11orf95 produces a C11orf95-MKL2 fusion protein (PubMed:20607705).
亞細(xì)胞定位：

Nucleus.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 29819

OMIM: 609463

KEGG: hsa:57496

STRING: 9606.ENSP00000339086

UniGene: Hs.49143

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