MIER1 Antibody
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中文名稱：MIER1兔多克隆抗體
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貨號：CSB-PA013823GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MIER1
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別名：MIER1 antibody; KIAA1610 antibody; Mesoderm induction early response protein 1 antibody; Early response 1 antibody; Er1 antibody; Mi-er1 antibody; hMi-er1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MIER1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.
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基因功能參考文獻：
- Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases PMID: 26938916
- Insulin and IGF-1 alter the subcellular localization of MIER1alpha in breast carcinoma cells. PMID: 26281834
- nuclear targeting of MIER1alpha requires an intact ELM2 domain and is dependent on interaction with HDAC1/2 PMID: 24376786
- the first immunohistochemical study of the MIER1alpha protein expression pattern in human tissues, is reported. PMID: 23277184
- Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells PMID: 22384264
- Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function. PMID: 12242014
- we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1). PMID: 12482978
- the association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters PMID: 15117948
- Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma PMID: 18665173
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亞細胞定位：[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.
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組織特異性：Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
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數據庫鏈接：
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