MIEN1 Antibody, Biotin conjugated

說明書

中文名稱：

MIEN1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA874795LD01HU
規格：

￥880
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MIEN1 Polyclonal antibody
Uniprot No.：

Q9BRT3
基因名：

MIEN1
別名：

C17orf37 antibody; C17orf37 homolog antibody; C35 antibody; chromosome 17 open reading frame 37 antibody; HBV X transactivated gene 4 protein antibody; HBV X-transactivated gene 4 protein antibody; HBV XAg transactivated protein 4 antibody; HBV XAg-transactivated protein 4 antibody; MGC14832 antibody; Mien1 antibody; MIEN1_HUMAN antibody; Migration and invasion enhancer 1 antibody; ORB3 antibody; Protein C17orf37 antibody; Protein C35 antibody; RDX12 antibody; Redox protein, 12-KD antibody; XTP4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Migration and invasion enhancer 1 protein (2-112AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
基因功能參考文獻：
1. these results suggest the MIEN1 promoter has a short interspersed nuclear Alu element region that is hypermethylated in normal cells leading to repression of the gene; in cancer, the hypomethylation of a part of this repeat, in addition to the binding of USF, results in MIEN1 expression PMID: 27589566
2. Data show that migration and invasion enhancer 1 (MIEN1) plays an essential role in maintaining the plasticity of the dynamic membrane-associated actin cytoskeleton, which leads to an increase in cell motility, suggesting targeting MIEN1 might represent a promising means to prevent breast tumor metastasis. PMID: 27462783
3. Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells. PMID: 28859163
4. indicate that MIEN1 overexpression may facilitate migration and invasion in breast cancer PMID: 28198505
5. In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment. PMID: 26827826
6. MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. PMID: 26272794
7. MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells. PMID: 25996585
8. C35 might serve as a biomarker or therapeutic target for management of colorectal cancer. PMID: 26173296
9. While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. PMID: 25406943
10. results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells. PMID: 23880825
11. Results suggest that MIEN1 may have an important regulatory role in phosphorylation of AKT with its redox potential. PMID: 23284973
12. prenylation is required for the function of the C17orf37 protein in cancer cells PMID: 21628459
13. Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells. PMID: 21068479
14. Data strongly suggest C17orf37 overexpression in prostate cancer functionally enhances migration and invasion of tumor cells, and is an important target for cancer therapy. PMID: 19503095
15. MGC14832 gene is located within human chromosome 17q12 amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes. PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human gastric cancer and breast cancer. PMID: 12739007
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亞細胞定位：

Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
蛋白家族：

SelWTH family
組織特異性：

Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein le
數據庫鏈接：

HGNC: 28230

OMIM: 611802

KEGG: hsa:84299

STRING: 9606.ENSP00000377778

UniGene: Hs.333526

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