MICAL1 Antibody, HRP conjugated
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中文名稱：MICAL1兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA851555LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MICAL1 Polyclonal antibody
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Uniprot No.：
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基因名：MICAL1
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別名：CasL interacting molecule antibody; DKFZp434B1517 antibody; FLJ11937 antibody; FLJ21739 antibody; MICA1_HUMAN antibody; MICAL 1 antibody; MICAL antibody; MICAL1 antibody; microtubule associated monoxygenase; calponin and LIM domain containing 1 antibody; Molecule interacting with CasL protein 1 antibody; NEDD9 interacting protein with calponin homology and LIM domains antibody; NEDD9-interacting protein with calponin homology and LIM domains antibody; NICAL antibody; OTTHUMP00000016969 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human [F-actin]-methionine sulfoxide oxidase MICAL1 protein (806-1067AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
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基因功能參考文獻：
- Methionine oxidation is regulated in vivo by monooxygenases of the MICAL family. (Review) PMID: 28229915
- describe methods to characterize MICAL-mediated F-actin disassembly using in vitro assays with purified proteins PMID: 27787846
- The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. PMID: 27430308
- The MICAL1 directly induce oxidation of actin molecules, leading to actin depolymerization. ROS production by MICAL1 also causes oxidation of collapsin response mediator protein-2 which subsequently undergoes phosphorylation. PMID: 23834433
- although MICAL1 is auto-inhibited by its C-terminal coiled-coil region, MICAL2 remains constitutively active and affects stress fibers, suggesting differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation PMID: 22331357
- Faint and scattered immunoreactivity for Mical-1 is observed in neurons of the neocortex of the temporal lobe epilepsy group, while strong immunoreactivity for Mical-1 is shown in control subjects. PMID: 21638339
- Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
- a CasL interacting molecule that associates with vimentin PMID: 11827972
- MICAL-1 isoforms with their multidomain structure are novel rab1 interacting proteins that function as scaffold proteins connecting different components in the cell. PMID: 12788069
- The unfolding of MICAL-1 calpolnin homology (CH) domain was studied. PMID: 17662518
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亞細(xì)胞定位：Cytoplasm. Cytoplasm, cytoskeleton. Midbody.
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蛋白家族：Mical family
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組織特異性：Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
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數(shù)據(jù)庫鏈接：
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