MEOX1 Antibody
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中文名稱：MEOX1兔多克隆抗體
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貨號：CSB-PA013695ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013695ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA013695ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MEOX1 Polyclonal antibody
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Uniprot No.：
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基因名：MEOX1
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別名：Homeobox protein MOX-1 antibody; MEOX1 antibody; MEOX1_HUMAN antibody; Mesenchyme homeo box 1 antibody; Mesenchyme homeobox 1 antibody; MOX 1 antibody; MOX1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Homeobox protein MOX-1 protein (1-254AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
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基因功能參考文獻：
- MEOX1 is a clinically relevant novel target in BCSCs and mesenchymal-like cancer cells in PTEN-deficient trastuzumab resistant breast cancer and may serve as target for future drug development. PMID: 27285982
- The G > A p.Q84X mutation in the MEOX1 is identified in Klippel-Feil syndrome. PMID: 24073994
- We describe a multiplex consanguineous family in which isolated KFS maps to a single 17q21.31 locus that harbors a homozygous frameshift deletion in MEOX1; this deletion results in complete instability of the transcript PMID: 23290072
- The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers. PMID: 22567123
- No mutations were identified in the PAX1 and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis PMID: 17764081
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相關疾?。?/div>Klippel-Feil syndrome 2, autosomal recessive (KFS2)亞細胞定位：Nucleus. Cytoplasm.數據庫鏈接：
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